"Adjuvant" external radiation of the mediastinum in radically resected non-small cell lung cancer

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
F M Smolle-JuettnerG Friehs

Abstract

The effect of postoperative external beam radiation in MO non-small cell lung cancer resected with curative intention was evaluated in a randomized trial. In 155 patients (121 males, 34 females; mean age: 59 years) 105 lobectomies, 12 bilobectomies and 38 pneumonectomies with radical lymph node dissection to the contralateral side were carried out. Histology revealed squamous cell (n = 68), adeno- (n = 53), large cell (n = 21), adenosquamous (n = 6) or bronchioloalveolar type (n = 7) carcinomas. The pathologic stages T1 (n = 38), T2 (n = 89), T3 (n = 28); NO (n = 39), N1 (n = 67), and N2 (n = 49) were evenly distributed between the two treatment groups: group A (72 patients) had no further oncologic treatment, while group B (83 patients) had external beam radiation to the mediastinum (50-56 Gy, 8 or 23 MeV photons, 2 Gy/day, 5 days a week) beginning 4 weeks after the operation. The overall 5-year survival rate of the whole collective was 24.1% without any significant difference between the radiotherapy group B (29.7%) and the control group A (20.4%) (log-rank test: P > 0.05). The overall 5-year recurrence-free survival rate was 20.1%, with no difference between groups B and A (radiotherapy: 22.7, controls: 15.6%, long-rank test...Continue Reading

Citations

Feb 8, 2003·The Lancet Oncology·Geoff DelaneyBin Jalaludin
Sep 16, 2000·Chest·R Arriagada, J P Pignon
Aug 24, 1999·Chest·M MachtayE Glatstein
Mar 23, 2010·Journal of Shoulder and Elbow Surgery·Raymond A Pensy, W Andrew Eglseder
May 22, 2010·Orthopaedics & Traumatology, Surgery & Research : OTSR·H BensafiJ Puget
Apr 16, 2003·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Samuel Cykert, Nancy Phifer
Dec 1, 2005·American Journal of Clinical Oncology·Daniel T ChangKenneth R Olivier
Jan 9, 2014·Expert Review of Anticancer Therapy·Tithi BiswasMitchell Machtay
Dec 3, 2008·Expert Review of Anticancer Therapy·Edgardo S SantosLuis E Raez
Oct 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MachtayE Glatstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.