Adjuvant high-dose intravenous immunoglobulin therapy can be easily and safely introduced as an alternative treatment in patients with severe pemphigus vulgaris: a retrospective preliminary study

American Journal of Clinical Dermatology
Michele Davide MignognaRaffaella Pagliuca

Abstract

Long-term corticosteroid therapy, often in association with other immunosuppressive agents, is considered the mainstay of pemphigus vulgaris (PV) therapy. Recent evidence has been changing this paradigm as patients who are non-responsive to conventional therapies or who experience severe adverse effects have been successfully treated with high-dose intravenous immunoglobulin (IVIg). However, the shift from conventional therapies to IVIg represents a major challenge in the daily practice of non-experienced clinicians because of potential adverse effects and other issues relevant to IVIg therapy such as the necessity for premedication, selection of cases, modality of infusion, patient monitoring, and the cost and length of hospital stay. The purpose of this preliminary study was to evaluate and report outcomes of treatment with IVIg in eight selected PV patients meeting clearly defined criteria for initiation of this therapy. Available guidelines for IVIg therapy in patients with autoimmune mucocutaneous blistering diseases were followed. Clinical response, induction and duration of remission, strategies for prevention of adverse effects, and total days of hospital stay in eight patients with severe PV treated with IVIg were retr...Continue Reading

References

Jun 1, 1988·Journal of the American Academy of Dermatology·N Korman
Jan 16, 1999·The Medical Clinics of North America·J E Scott, A R Ahmed
Jan 23, 1999·The New England Journal of Medicine·Z Yu, V A Lennon
Feb 25, 2000·Journal of the American Academy of Dermatology·A Herbst, J C Bystryn
Dec 2, 2000·Journal of the American Academy of Dermatology·L EngineerA R Ahmed
Jul 24, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·K C BholA R Ahmed
Oct 19, 2001·Journal of the American Academy of Dermatology·M V Dahl, A G Bridges
Nov 14, 2001·Clinics in Dermatology·G G Tóth, M F Jonkman
Aug 28, 2002·Journal of the American Academy of Dermatology·Jean-Claude BystrynSteven Natow
Sep 26, 2003·Transfusion·Irina Knezevic-Maramica, Margot S Kruskall
Jan 27, 2004·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·D K GuptaM Srinivas
Jun 23, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Daphna ParanRonen Ben-Ami
Jul 5, 2005·Lancet·Jean-Claude Bystryn, Jennifer L Rudolph
Jul 12, 2005·The Journal of Clinical Investigation·Fangming LinPeter Igarashi
Sep 24, 2005·Clinical and Experimental Immunology·S JollesS A Misbah
Nov 15, 2005·The Journal of Clinical Investigation·Ning LiZhi Liu
Nov 30, 2005·The American Journal of Pathology·Juan ArredondoSergei A Grando
Dec 16, 2005·The Journal of Investigative Dermatology·Jean-Claude Bystryn, Jennifer L Rudolph
Mar 1, 2006·International Immunopharmacology·Jerry Siegel
Mar 1, 2006·International Immunopharmacology·Jagadeesh BayrySrini Kaveri
Mar 1, 2006·International Immunopharmacology·David J Hamrock
Mar 1, 2006·International Immunopharmacology·A Razzaque Ahmed
Mar 1, 2006·International Immunopharmacology·Erwin W Gelfand
Mar 1, 2006·International Immunopharmacology·A Razzaque Ahmed
Oct 27, 2006·The New England Journal of Medicine·A Razzaque AhmedMarshall R Posner

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Citations

Oct 27, 2015·Expert Review of Clinical Pharmacology·Gholamreza AziziAsghar Aghamohammadi
May 3, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·R McMillanD Sirois
Jun 10, 2014·The Journal of Dermatology·Masayuki AmagaiYasuo Kitajima
Mar 9, 2021·Journal of the American Academy of Dermatology·Carmen M MontagnonStanislav N Tolkachjov

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