Adjuvant Hormonal Therapy for Low-Grade Endometrial Stromal Sarcoma

Reproductive Sciences
Uma DeshmukhPeter E Schwartz

Abstract

To compare aromatase inhibitors (AIs) with progestins as adjuvant hormonal therapy(AHT) for low-grade endometrial stromal sarcomas (LGESSs). We reviewed cases with LGESS at our institution from 1984 to 2017. Disease recurrence and recurrence-free survival (RFS) were assessed among patients who received AI, progestins, or no AHT. Among 39 patients with LGESS, 18 received progestins, 13 received AI, and 8 received no AHT. Thirty patients had stage I disease, and 9 had stage II to IV disease. All underwent hysterectomies. Disease recurred in 70% (7/10) of stage I patients who received no AHT, compared to 14.3% (1/7) receiving AI, and 7.7% (1/13) receiving progestins ( P = .003). Among stage I patients taking AI, mean RFS was 153.1 months (95% confidence interval [CI]: 110-195.6) versus 306.2 months (95% CI: 259.7-352.6) for progestin patients and 90.8 months (95% CI: 56.8-124.9) for those who received no AHT. In stage II to IV patients, mean RFS was 148.5 months (95% CI: 148.5-148.5) and 120.8 months (95% CI: 55.8-185.9) for the AI and progestin groups, respectively. All stage II to IV patients received AHT. Among stage I patients, median follow-up time for RFS was 159.1 months for progestin patients, 52.6 months for AI, and 53.1 ...Continue Reading

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Citations

Oct 5, 2019·Archives of Gynecology and Obstetrics·Ran CuiZhenyu Zhang
Oct 17, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Volkan KarataşlıMuzaffer Sancı
Aug 21, 2021·Journal of Zhejiang University. Science. B·Chunhui Li, Chunhong Wang
Sep 22, 2021·BMJ Case Reports·Raghavendran AsokanSriram Krishnamoorthy

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