PMID: 1212660Dec 1, 1975Paper

Adjuvant immunotherapy and chemoimmunotherapy in colorectal cancer of the Dukes' C classification. Preliminary clinical results

Cancer
G M MavligitE M Hersh

Abstract

Fifty-eight patients with Dukes' C classification of carcinoma of the large bowel were placed on adjuvant immuno- or chemoimmunotherapy with Bacillus calmette guerin (BCG) or combination of 5-fluorouracil (5-FU) plus BCG following primary and definitive surgery, and were followed for up to 21 months. Of twenty-six patients receiving BCG alone by scarification, five have relapsed with 75% of freedom from disease estimated at 15.1 months compared with 10.1 months in a group of carefully selected historical controls who had surgery alone (p = 0.12). The survival of all patients receiving BCG alone has not reached the 75 percentile yet, and the difference from controls is currently estimated at the 18% level. The combination of 5-FU plus BCG (studied in 32 patients) may be superior to BCG alone at this time, in that it appears to more effectively protect against tumor recurrence (75 percentile not yet reached compared to control, (p = 0.08). The survival of patients on 5-FU plus BCG also appears to be improved (p = 0.09). No patients have expired compared to a 75 percentile survival of 16.6 months in the control. Serial determination of plasma CEA was crucial in the clinical follow-up of these patients. Frequent CEA detetminations ...Continue Reading

References

Jun 26, 1975·The New England Journal of Medicine·A R Feinstein
Apr 1, 1970·Archives of Surgery·S MackmanF J Ansfield
Dec 1, 1969·British Journal of Cancer·G MathéF Lapeyraque
Nov 1, 1974·The American Journal of Digestive Diseases·G M MavligitE M Hersh
Jan 20, 1973·British Medical Journal·D CrowtherR B Scott
Nov 7, 1974·The New England Journal of Medicine·E P CortesO Glidewell
Nov 1, 1973·Journal of the National Cancer Institute·E Hawrylko, G B Mackaness
Jan 24, 1974·The New England Journal of Medicine·E A Gehan, E J Freireich
Nov 7, 1974·The New England Journal of Medicine·N JaffeY Bishop
Dec 5, 1974·The New England Journal of Medicine·J E SokalM Snyderman
Mar 1, 1972·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·M M KligermanR Vera
Sep 1, 1973·Radiology·A Rodriguez-AntúnezT W Hunter
Oct 1, 1973·American Journal of Surgery·R C Donaldson
Oct 1, 1973·British Journal of Cancer·R W Baldwin, M V Pimm
Mar 15, 1974·International Journal of Cancer. Journal International Du Cancer·R L StolfiD S Martin
May 1, 1972·Diseases of the Colon and Rectum·L M RousselotB S Pasternack
Jul 15, 1971·The New England Journal of Medicine·P Lo GerfoH J Hansen

❮ Previous
Next ❯

Citations

Nov 20, 2012·Oncoimmunology·Erika VacchelliGuido Kroemer
Apr 1, 1977·Diseases of the Colon and Rectum·R E FalkB Langer
Sep 1, 1982·Cancer Treatment Reviews·J M Gilbert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.