Adjuvant Immunotherapy to Improve Outcome in High-Risk Pediatric Sarcomas.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Melinda S MerchantCrystal L Mackall

Abstract

Patients with metastatic or relapsed pediatric sarcomas receive cytotoxic regimens that induce high remission rates associated with profound lymphocyte depletion, but ultimately few survive long term. We administered adjuvant immunotherapy to patients with metastatic and recurrent pediatric sarcomas in an effort to improve outcomes. Mononuclear cells were collected via apheresis, and tumor lysate was acquired via percutaneous biopsy at enrollment. Participants received standard antineoplastic therapy, followed by autologous lymphocytes, tumor lysate/keyhole limpet hemocyanin-pulsed dendritic cell vaccinations ± recombinant human IL7. Primary outcomes were toxicity and vaccine responses. Secondary outcomes were immune reconstitution, event-free survival, and overall survival (OS). Forty-three patients enrolled and 29 received immunotherapy. The regimen was well tolerated. Intent-to-treat analysis demonstrated 5-year OS of 51% with significant differences based upon histologic group (63% vs. 0% for Ewing/rhabdomyosarcoma vs. other sarcomas) and response to standard therapy (74% no residual disease vs. 0% residual disease). Five-year intent-to-treat OS of patients with newly diagnosed metastatic Ewing/rhabdomyosarcoma was 77%, hig...Continue Reading

References

Jan 19, 1995·The New England Journal of Medicine·C L MackallS M Steinberg
May 29, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M PaulussenH Jürgens
Nov 5, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A S PappoH E Grier
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M CristS S Donaldson
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M E MerinoC L Mackall
Sep 21, 2002·Cancer Cell·Crystal L MackallLee J Helman
Oct 31, 2002·Nature Immunology·Gavin P DunnRobert D Schreiber
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John C BrenemanWilliam M Crist
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James S MiserHolcolmbe E Grier
Dec 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M CarliM Stevens
Feb 25, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C G StevensOdile Oberlin
Jul 8, 2005·Journal of Immunotherapy·Daniel J PowellSteven A Rosenberg
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark L BernsteinUNKNOWN Children's Oncology Group
Aug 8, 2006·British Journal of Haematology·Mustaqeem SiddiquiLuis F Porrata
Oct 5, 2006·International Journal of Cancer. Journal International Du Cancer·Joannes F M JacobsI Jolanda M de Vries
Dec 7, 2006·Cancer Immunology, Immunotherapy : CII·Melinda S MerchantCrystal L Mackall
Jan 19, 2007·Journal of Pediatric Hematology/oncology·Guillermo De AnguloEugenie S Kleinerman
May 8, 2007·Journal of Pediatric Hematology/oncology·Steven G DuBoisHolcombe E Grier
Sep 25, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Bipin N SavaniA John Barrett
May 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Odile OberlinJames R Anderson
Aug 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Crystal L MackallLee J Helman
Apr 22, 2009·Blood·Irini SeretiUNKNOWN ACTG 5214 Study Team
Aug 8, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Katarina Le BlancMats Remberger
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Claude SportèsRonald E Gress
Jun 16, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ruth LadensteinHeribert Jürgens
Jan 12, 2011·Annual Review of Immunology·Matthew D VeselyMark J Smyth
Jul 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stuart A GrossmanUNKNOWN NABTT CNS Consortium
Feb 3, 2012·Pediatric Hematology and Oncology·Jenny PotratzAlan Craft
Oct 24, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard B WomerAaron R Weiss
Nov 20, 2014·The New England Journal of Medicine·Alexandra SnyderTimothy A Chan
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll

❮ Previous
Next ❯

Citations

Jul 5, 2017·Pediatric Blood & Cancer·Angela C WeyandValerie P Opipari
Sep 5, 2017·Pediatric Blood & Cancer·Christian SpurnyClaudia Rossig
Feb 16, 2018·Virchows Archiv : an International Journal of Pathology·Isidro MachadoAntonio Llombart-Bosch
Dec 1, 2017·Immunotherapy·Shinji MiwaHiroyuki Tsuchiya
Jan 9, 2019·Nature Reviews. Disease Primers·Stephen X SkapekDouglas S Hawkins
Jan 10, 2019·International Journal of Molecular Sciences·Shinji MiwaHiroyuki Tsuchiya
Jul 6, 2019·Frontiers in Oncology·Dana L CaseyNai-Kong V Cheung
Sep 25, 2019·Cancers·Sévérine de BruijnEva Lion
Oct 13, 2016·Oncotarget·Amanda R DancsokTorsten O Nielsen
Oct 16, 2016·Oncotarget·Hongjiu YuLin Huang
Jul 19, 2017·Journal for Immunotherapy of Cancer·Simran SindhuAndrew S Kraft
Sep 2, 2018·Molecular and Cellular Pediatrics·Stefan E G BurdachKlaus-Michael Debatin
Jan 30, 2019·Journal of Oncology·Shinji MiwaHiroyuki Tsuchiya
Jul 7, 2018·Nature Reviews. Disease Primers·Thomas G P GrünewaldUta Dirksen
Dec 24, 2018·Cancers·Alexandra PenderSeth Pollack
Jul 18, 2019·Journal of Hematology & Oncology·Kyle A DysonElias J Sayour
Jul 2, 2020·OncoTargets and Therapy·Deepam PushpamBivas Biswas
Jun 24, 2017·Stem Cells International·Alexander J Hron, Atsushi Asakura
Nov 21, 2019·Nature Immunology·João T BarataBenedict Seddon
Jul 8, 2020·Cancers·Shinji MiwaHiroyuki Tsuchiya
Mar 30, 2019·Journal for Immunotherapy of Cancer·Christine Ménétrier-CauxChristophe Caux
Feb 23, 2020·Der Pathologe·Albert RoessnerJohannes Haybäck
Jul 14, 2019·Nature Reviews. Cancer·David T W JonesStefan M Pfister
Dec 10, 2020·Journal for Immunotherapy of Cancer·Erin MoralesDjordje Atanackovic
Jan 23, 2021·Critical Reviews in Oncology/hematology·Michael I Koukourakis, Alexandra Giatromanolaki
Feb 26, 2021·Pathology International·Albert RoessnerDoerthe Jechorek
Feb 27, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S MiwaH Tsuchiya
Apr 17, 2021·Neuro-oncology Advances·Hannah E OlsenJoshua D Bernstock
Jun 12, 2021·Seminars in Cancer Biology·Mirjam Blattner-JohnsonElke Pfaff
Aug 8, 2021·Cancers·Tânia Fortes-AndradePaulo Rodrigues-Santos
Aug 10, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Fan TangXia-Wei Wei
Apr 4, 2017·Cancer Cell·Robbie G MajznerCrystal L Mackall

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Crystal L MackallLee J Helman
International Journal of Urology : Official Journal of the Japanese Urological Association
Akihiko MatsumotoTadaichi Kitamura
© 2021 Meta ULC. All rights reserved