Adjuvant leuprolide in normal, abnormal, and poor responders to controlled ovarian hyperstimulation for in vitro fertilization/gamete intrafallopian transfer

Fertility and Sterility
M SathanandanC D Matthews

Abstract

Fifty patients (normal responders) received either human menopausal gonadotropin (hMG) alone (control group) or leuprolide + hMG (leuprolide group). The use of leuprolide was associated with a reduction of hMG requirements (14.8 versus 17.8 ampules, P = 0.02) and the abolition of spontaneous luteinizing hormone surges (nil versus 3, P = 0.006). The rate of fertilization (87% versus 65%, P = 0.003) was higher in the leuprolide group. Pituitary and ovarian suppression was effected for 16 subjects who had previously shown a poor follicular response and a further 19 subjects who had previously responded abnormally. The poor responders required more hMG (43.9 versus 27.1 ampules, P less than 0.001), achieved a lower estradiol maximum (5.1 versus 12.1 nmol/l, P less than 0.001), and had fewer oocytes recovered (4.1 versus 11.5, P less than 0.001), than the abnormal responders.

Citations

Sep 1, 1992·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·D MeirowJ G Schenker
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Zabeena PandianSiladitya Bhattacharya
Jan 1, 1991·Annals of the New York Academy of Sciences·K Gordon, G D Hodgen
Nov 13, 2015·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisSiladitya Bhattacharya
Dec 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Z Ben-RafaelD Feldberg

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