Adjuvant Radiation is Associated with Improved Survival for Select Patients with Non-metastatic Adrenocortical Carcinoma

Annals of Surgical Oncology
Daniel W NelsonMelanie Goldfarb

Abstract

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy for which surgery is the mainstay of treatment and for which adjuvant radiation is infrequently employed; however, small, single-institution series suggest adjuvant radiation may improve outcomes. All patients with non-metastatic ACC treated with either surgery alone or surgery followed by adjuvant radiation were identified in the 2004-2013 National Cancer Database. Factors associated with receipt of radiation and the impact of adjuvant radiation on survival were determined by multivariable analysis. Of 1184 patients, 171 (14.4%) received adjuvant radiation. Patient demographics were similar between the two groups, but those receiving radiation were more likely to have had positive margins following surgery (37.4 vs. 14.6%; p < 0.001), evidence of vascular invasion (14.0 vs. 5.1%; p = 0.05), and receive concurrent chemotherapy (57.3 vs. 28.8%; p < 0.001). After adjustment for tumor and other treatment factors, only positive margins following surgery was associated with an increased likelihood of receiving adjuvant radiation (odds ratio 3.84, 95% confidence interval [CI] 1.95-7.56). Radiation therapy did not confer a difference in median overall survival in the g...Continue Reading

References

Apr 1, 1991·American Journal of Clinical Oncology·A M MarkoeL W Brady
Nov 1, 1987·Clinical Radiology·B J MageeD Pearson
Dec 30, 2003·Journal of Surgical Oncology·David P WinchesterR Scott Jones
Mar 23, 2006·The Journal of Clinical Endocrinology and Metabolism·Bruno Allolio, Martin Fassnacht
May 9, 2006·World Journal of Surgery·Electron KebebewAlex McMillan
Aug 10, 2006·The Journal of Clinical Endocrinology and Metabolism·Martin FassnachtBruno Allolio
Jun 8, 2007·The New England Journal of Medicine·Massimo TerzoloAlfredo Berruti
Apr 30, 2009·Cancer·Buelent PolatMichael Flentje
Jul 30, 2010·The Journal of Clinical Endocrinology and Metabolism·Martin FassnachtUNKNOWN German ACC Registry Group
Aug 3, 2010·International Journal of Radiation Oncology, Biology, Physics·Aaron SabolchEdgar Ben-Josef
May 4, 2012·The New England Journal of Medicine·Martin FassnachtUNKNOWN FIRM-ACT Study Group
Jul 23, 2013·The Cancer Journal·Jennifer HoAradhana Kaushal
Mar 11, 2015·International Journal of Radiation Oncology, Biology, Physics·Aaron SabolchShruti Jolly
Jul 21, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Victor SrougiMaria C B V Fragoso

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Citations

Jun 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Laila A GharzaiShruti Jolly
Aug 31, 2019·Hormones & Cancer·Dwight H OwenBhavana Konda
Feb 27, 2020·Cancers·Sara BedroseMouhammed Amir Habra
Feb 25, 2019·Current Oncology Reports·Sina Jasim, Mouhammed Amir Habra
Jan 29, 2021·Critical Reviews in Oncology/hematology·Alba FiorentinoVittorio Donato
Mar 13, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Darko KastelanTina Dusek
Aug 6, 2021·Therapeutic Advances in Chronic Disease·Omair A Shariq, Travis J McKenzie

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