Adjuvant radiation therapy improves local control after surgical resection in patients with localized adrenocortical carcinoma

International Journal of Radiation Oncology, Biology, Physics
Aaron SabolchShruti Jolly

Abstract

Adrenocortical carcinoma (ACC) is a rare malignancy known for high rates of local recurrence, though the benefit of postoperative radiation therapy (RT) has not been established. In this study of grossly resected ACC, we compare local control of patients treated with surgery followed by adjuvant RT to a matched cohort treated with surgery alone. We retrospectively identified patients with localized disease who underwent R0 or R1 resection followed by adjuvant RT. Only patients treated with RT at our institution were included. Matching to surgical controls was on the basis of stage, surgical margin status, tumor grade, and adjuvant mitotane. From 1991 to 2011, 360 ACC patients were evaluated for ACC at the University of Michigan (Ann Arbor, MI). Twenty patients with localized disease received postoperative adjuvant RT. These were matched to 20 controls. There were no statistically significant differences between the groups with regard to stage, margins, grade, or mitotane. Median RT dose was 55 Gy (range, 45-60 Gy). Median follow-up was 34 months. Local recurrence occurred in 1 patient treated with RT, compared with 12 patients not treated with RT (P=.0005; hazard ratio [HR] 12.59; 95% confidence interval [CI] 1.62-97.88). Howev...Continue Reading

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Citations

Aug 19, 2015·Annals of Surgical Oncology·Neda AminiTimothy M Pawlik
Sep 19, 2015·International Journal of Radiation Oncology, Biology, Physics·Aaron Sabolch, Shruti Jolly
Sep 19, 2015·International Journal of Radiation Oncology, Biology, Physics·Kiran PurushothamanGeetha Muttath
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