Adjuvant radiotherapy for gastric cancer: A dosimetric comparison of 3-dimensional conformal radiotherapy, tomotherapy and conventional intensity modulated radiotherapy treatment plans

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
Max DaheleYee C Ung

Abstract

Some patients with gastric cancer benefit from post-operative chemo-radiotherapy, but adequately irradiating the planning target volume (PTV) whilst avoiding organs at risk (OAR) can be difficult. We evaluate 3-dimensional conformal radiotherapy (CRT), conventional intensity-modulated radiotherapy (IMRT) and helical tomotherapy (TT). TT, 2 and 5-field (F) CRT and IMRT treatment plans with the same PTV coverage were generated for 5 patients and compared. Median values are reported. The volume of left/right kidney receiving at least 20Gy (V20) was 57/51% and 51/60% for 2 and 5F-CRT, and 28/14% for TT and 27/19% for IMRT. The volume of liver receiving at least 30Gy (V30) was 45% and 62% for 2 and 5F-CRT, and 37% for TT and 35% for IMRT. With TT, 98% of the PTV received 95-105% of the prescribed dose, compared with 45%, 34% and 28% for 2F-CRT, 5F-CRT and IMRT respectively. Using conventional metrics, conventional IMRT can achieve comparable PTV coverage and OAR sparing to TT, but at the expense of PTV dose heterogeneity. Both irradiate large volumes of normal tissue to low doses. Additional studies are needed to demonstrate the clinical impact of these technologies.

References

Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J R Cassady
Mar 2, 2002·International Journal of Radiation Oncology, Biology, Physics·Stephen R SmalleyTyvin Rich
Aug 27, 2002·International Journal of Radiation Biology·S KöstT Herrmann
Mar 11, 2003·Technology in Cancer Research & Treatment·James S WelshMinesh P Mehta
Jul 23, 2003·Physics in Medicine and Biology·Steve B JiangGeorge T Y Chen
Mar 15, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Trevor LeongSamuel Y K Ngan
May 17, 2005·Journal of Surgical Oncology·John S Macdonald
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Cesar Della BianciaJoachim Yahalom
Jun 28, 2005·International Journal of Radiation Oncology, Biology, Physics·Jolie RingashLaura Dawson
Aug 4, 2005·Cancer·Loren K MellArno J Mundt
Apr 22, 2006·International Journal of Radiation Oncology, Biology, Physics·Zahra KassamJolie Ringash
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Sep 29, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Richard D PeznerJeffrey Y C Wong
Oct 3, 2006·Seminars in Radiation Oncology·Randall K Ten Haken, Theodore S Lawrence
Dec 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Edwin P M JansenMarcel Verheij
Dec 22, 2006·Physics in Medicine and Biology·Brian KanagakiKe Sheng
Feb 6, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ke ShengPaul W Read
Mar 3, 2007·International Journal of Radiation Oncology, Biology, Physics·X Allen LiJ Frank Wilson
Mar 14, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eric D EhlerWolfgang A Tomé
Mar 31, 2007·International Journal of Radiation Oncology, Biology, Physics·David CraftThomas Bortfeld
Apr 24, 2007·Acta Oncologica·Theodoros FoukakisPehr A Lind
May 26, 2007·Journal of Gastroenterology and Hepatology·Khay-Guan Yeoh
Jun 16, 2007·International Journal of Radiation Oncology, Biology, Physics·Tiezhi ZhangBhudatt Paliwal
Jul 11, 2007·The Cancer Journal·Kimmie NgCharles S Fuchs

❮ Previous
Next ❯

Citations

Oct 15, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Harun BadakhshiVolker Budach
Jul 6, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·M FooT Leong
Dec 6, 2011·International Journal of Radiation Oncology, Biology, Physics·Twisha ChakravartyPrajnan Das
Jun 25, 2015·Revista da Associação Médica Brasileira·E WeltmanUNKNOWN Brazilian Society for Radiation Oncology
Apr 6, 2019·Indian Journal of Cancer·Prameela G ChelakkotDurgapoorna Menon
Apr 5, 2019·Oncology Letters·Zhongsong ManZaixiang Tang
Sep 14, 2017·International Journal of Oncology·Jin ZhouZaixiang Tang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved