Adjuvant radiotherapy in stage IV diffuse large cell lymphoma improves outcome

Leukemia & Lymphoma
A AvilésSergio Cleto

Abstract

The role of adjuvant radiotherapy to sites of nodal bulky disease in patients with aggressive diffuse large cell lymphoma (DLCL), and stage IV remain undefined. We began a prospective controlled clinical trial to evaluate impact in event free survival (EFS) and overall survival (OS) in a large cohort of patients with a longer follow-up. Between 1989 and 1995; 341 patients with aggressive DLCL and presence of nodal bulky disease (tumor mass > 10 cm) in pathological proven complete response after intensive chemotherapy were randomized to received either radiotherapy (involved fields, 40 Gy) or not. The 5-year EFS and OS in radiated patients were respectively: 82% (95% Confidence interval (CI): 70-89%) and 87% (95% 80-99%), that were statistically significant to control group: 55% (41-64%) (P < 0.001) and 66% (95% CI: 51-73%) (P < 0.01) respectively. Radiotherapy was well tolerated, acute toxicity was mild and until now late toxicity did not appear. The use of adjuvant radiotherapy improve EFS and OS and probably the possibility of cure in patients diffuse large cell lymphoma with worse prognostic factors. Thus, we felt that adjuvant radiotherapy will be considered as part of the initial treatment in this setting of patients.

References

Jan 1, 1992·Critical Reviews in Oncology/hematology·M R MirzaL Specht
Feb 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J M CossetM Tubiana
Nov 15, 1994·International Journal of Radiation Oncology, Biology, Physics·A AvilésJ C Díaz-Maqueo
Jan 1, 1995·International Journal of Radiation Oncology, Biology, Physics·L M FullerJ L Palmer
May 29, 1999·International Journal of Radiation Oncology, Biology, Physics·S S KamathN P Mendenhall
Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·P J SchlembachJ D Cox
Jun 8, 2001·International Journal of Radiation Oncology, Biology, Physics·R B WilderJ D Cox

❮ Previous
Next ❯

Citations

Mar 1, 2007·Nature Clinical Practice. Oncology·Søren M BentzenJacques Bernier
Aug 3, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J A DorthC R Kelsey
Mar 24, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Chul S HaMary K Gospodarowicz
Aug 13, 2015·Cancer Metastasis Reviews·Fernando MendesManuel Santos Rosa
Feb 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerhard HeldMichael Pfreundschuh

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.