PMID: 7545763Aug 1, 1995Paper

Adjuvant recombinant human growth hormone stimulates insulin-like growth factor binding protein-3 secretion in critically ill trauma patients

The Journal of Trauma
S R PetersenN J Holaday

Abstract

The early catabolic phase of severe injury is associated with acute growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein-3 (IGFBP-30 deficiency. The metabolic half-life of circulating IGF-1 is prolonged by its binding to IGFBP-3. The role of this binding protein in nutritionally repleted multiple-injury patients has not been previously evaluated. We have measured plasma levels of these polypeptides and nitrogen (N) balance in 18 adult (15 males/3 females; mean age, 45 years), severely injured, hypermetabolic, and highly catabolic trauma patients within 48 to 60 hours after injury, when they were receiving maintenance fluids without calories or N and during 6 days of total parenteral nutrition (TPN). Before instituting TPN, the patients were randomized to receive (group H, n = 9) or not to receive (group C, n = 9) daily recombinant human growth hormone (rhGH), 0.15 mg/kg IM. Adjuvant rhGH significantly increases plasma levels of GH, IGF-1, IGFBP-3, and insulin. In addition, it shows better improvement in N balance. The bioavailability of IGF-1 is increased, as indicated by the decrease in IGFBP-3:IGF-1 ratio. A significant correlation between IGF-1 and IGFBP-3 levels is presen...Continue Reading

References

Jan 1, 1991·Annual Review of Nutrition·D R Clemmons, L E Underwood
Jul 1, 1981·The Journal of Clinical Endocrinology and Metabolism·R M WhiteR E Johnsonbaugh
Dec 1, 1981·The Journal of Clinical Endocrinology and Metabolism·D R ClemmonsJ J Van Wyk
Dec 1, 1992·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M JeevanandamS R Petersen

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Citations

Sep 14, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·R C BaxterS R Holman

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