Adjuvant sorafenib therapy in patients with resected hepatocellular carcinoma: evaluation of predictive factors

Medical Oncology
Wei ZhangTianqiang Song

Abstract

Currently there is no predictor for survival after adjuvant sorafenib in patients with hepatocellular carcinoma (HCC) who have undergone curative resection. Thirty-eight patients who underwent curative resection of HCC received adjuvant sorafenib therapy between August 2009 and March 2012. Clinicopathological parameters including patient factors, tumor factors, liver background, and inflammatory factors (before surgery and dynamic changes after sorafenib therapy) were evaluated to identify predictors for overall survival (OS) and recurrence-free survival (RFS). The recurrence rate, mortality rate, and clinicopathological data were also compared. Increased NLR after sorafenib (HR = 3.199, 95 % CI 1.365-7.545, P = 0.008), increased GGT after sorafenib (HR = 3.204, 95 % CI 1.333-7.700, P = 0.009), and the presence of portal vein thrombosis (HR = 2.381, 95 % CI 1.064-5.328, P = 0.035) were risk factors related to RFS. By contrast, increased NLR after sorafenib was the only independent risk factor related to OS (HR = 4.647, 95 % CI 1.266-17.053, P = 0.021). Patients with increased NLR or increased GGT after sorafenib had a higher incidence of recurrence and death. Patients who had increased NLR tended to have higher preoperative lev...Continue Reading

References

Dec 20, 2003·Journal of Cancer Research and Clinical Oncology·Zhao-You TangKang-Da Liu
Feb 8, 2005·Atherosclerosis·Duk-Hee Lee, David R Jacobs
Apr 7, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Yasuaki SaijoReiko Kishi
May 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xiao-Dong ZhuHui-Chuan Sun
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Sep 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Dec 22, 2009·Future Oncology·Campbell S D Roxburgh, Donald C McMillan
Jun 24, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei ZhangZhao-You Tang
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Oct 25, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Daniel KeizmanMichael A Carducci
Dec 20, 2011·The Journal of Urology·Yoshio OhnoMasaaki Tachibana
Dec 19, 2012·Nature Reviews. Clinical Oncology·Shigeo Masuda, Juan Carlos Izpisua Belmonte
Aug 24, 2013·Nature Reviews. Cancer·Sarah Seton-Rogers
Oct 3, 2013·British Journal of Cancer·S BaltaT Celik
Jul 8, 2014·The Journal of Surgical Research·Wei PengMing-Qing Xu
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Sep 30, 2014·Drug Discoveries & Therapeutics·Jialu Chen, Jianjun Gao

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