Adjuvant stereotactic radiosurgery after resection of intracranial hemangiopericytomas

International Journal of Radiation Oncology, Biology, Physics
Hideyuki KanoL Dade Lunsford

Abstract

To evaluate adjuvant stereotactic radiosurgery (SRS) in the management of recurrent or residual intracranial hemangiopericytomas (HPCs), we assessed tumor control, survival, and complications in patients who had undergone gamma knife SRS as part of multimodal therapy. We retrospectively reviewed the records of consecutive 20 HPC patients who had undergone SRS for 29 tumors. The median patient age was 51.5 years (range, 8.9-80.2). All patients had undergone previous surgical resection of their tumors. In addition, 12 patients underwent fractionated radiotherapy before SRS. Of the 20 patients, 16 patients had low-grade HPCs (20 tumors) and 4 had high-grade anaplastic HPCs (9 tumors). The median radiosurgery target volume was 4.5 cm(3) (range, 0.07-34.3), and the median marginal dose was 15.0 Gy (range, 10-20). At an average of 48.2 months (range, 7.2-124.1), 5 patients had died of metastases and 3 patients had died of disease progression. The overall survival after radiosurgery was 100%, 85.9%, and 13.8% at 1, 5, and 10 years, respectively. The follow-up imaging studies demonstrated tumor control in 21 (72.4%) of 29 tumors. The progression-free survival rate after SRS at 1, 3, and 5 years was 89.1% for low-grade HPCs and 88.9%, 6...Continue Reading

References

Jan 1, 1975·Journal of Neurology·K Jellinger, F Slowik
Jul 18, 2000·Acta neurochirurgica·B R PayneL Steiner
Sep 18, 2002·Neurosurgery·Jason SheehanL Dade Lunsford
Jan 27, 2005·Neurosurgical Focus·Steven D Chang, Gordon T Sakamoto

❮ Previous
Next ❯

Citations

Jun 8, 2011·Journal of Hematology & Oncology·Anand VeeravaguSteven D Chang
Apr 7, 2010·Journal of Neurosurgery·Martin J RutkowskiAndrew T Parsa
Nov 16, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Rohan RamakrishnaManuel Ferreira
Nov 26, 2010·Acta neurochirurgica·K ZweckbergerU Schick
Nov 19, 2013·World Neurosurgery·Angelina Graziella MeloneAntonio Santoro
Sep 16, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Martin J RutkowskiAndrew T Parsa
Oct 19, 2011·Neurological Research·Douglas KondziolkaL Dade Lunsford
Apr 23, 2016·Journal of Neurosurgery·Or Cohen-InbarJason Sheehan
Oct 23, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Byung Sup KimJung-Il Lee
Oct 29, 2014·American Journal of Clinical Oncology·Abhimanyu GhoseRekha Chaudhary
May 20, 2018·Journal of Medical Imaging and Radiation Oncology·Rohan NairMichael Dally
Oct 3, 2014·Rare Tumors·Charlotte Dai KubickySimon S Lo
Mar 10, 2018·Journal of Neurosurgery·Kyoung Su SungJong Hee Chang
Oct 15, 2019·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Or Cohen-Inbar
Jan 20, 2010·Journal of Neuro-oncology·Jin Wook KimHee-Won Jung
Jul 10, 2014·Journal of Neuro-oncology·William R CopelandBruce E Pollock
Jan 13, 2018·Journal of Neuro-oncology·Seung Hyuck JeonIl Han Kim
Oct 9, 2019·NMC Case Report Journal·Kosuke NakajoKazuhiro Yamanaka
Jan 1, 2012·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Cristina PradoFerran Guedea
Nov 9, 2020·Bulletin du cancer·Marine LottinNicolas Penel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.