Adjuvant systemic chemotherapy with or without bevacizumab in patients with resected pulmonary metastases from colorectal cancer

Thoracic Cancer
Nedim TuranAnatolian Society of Medical Oncology (ASMO)

Abstract

We investigated the impact of modern chemotherapy regimens and bevacizumab following pulmonary metastasectomy (PM) from metastatic colorectal cancer (CRC). A total of 122 consecutive patients who were curatively resected for pulmonary metastases of CRC in twelve oncology centers were retrospectively analysed between January 2000 and April 2012. Of 122 patients, 14 did not receive any treatment following PM. The remaining 108 patients received fluoropyrimidine-based (n = 12), irinotecan-based (n = 56) and oxaliplatin-based (n = 40) chemotherapy combinations. Among these, 52 patients received bevacizumab (BEV) while 56 did not (NoBEV). Median recurrence-free survival (RFS) was 17 months and median overall survival (OS) has not been reached at a median follow-up of 25 months after PM. Three and five-year OS rates were 66% and 53%, respectively. RFS and OS were similar, irrespective of the chemotherapy regimen or BEV use. Positive pulmonary margin, KRAS mutation status, and previous liver metastasectomy were negative independent prognostic factors for RFS, while pathologically confirmed thoracic lymph node involvement was the only negative independent prognostic for OS in multivariate analysis. No significant RFS or OS difference w...Continue Reading

References

Jan 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·U PastorinoUNKNOWN International Registry of Lung Metastases
Sep 28, 2000·The New England Journal of Medicine·L B SaltzL L Miller
Sep 5, 2001·British Journal of Cancer·H J AndreyevN Urosevic
Nov 24, 2001·Surgical Oncology·R S DavidsonT M Anderson
Oct 31, 2002·The Journal of Thoracic and Cardiovascular Surgery·Yukihito SaitoMasaharu Nakade
Dec 6, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christophe TournigandAimery de Gramont
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Jul 1, 2005·The New England Journal of Medicine·Chris TwelvesWerner Scheithauer
Jul 7, 2005·Journal of the National Cancer Institute·William L InceHartmut Koeppen
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel G HallerRobert J Mayer
Nov 17, 2006·International Journal of Colorectal Disease·Won-Suk LeeYoung Mog Shim
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Philip KueblerNorman Wolmark
Jun 26, 2007·The Annals of Thoracic Surgery·Joachim PfannschmidtHans Hoffmann
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles S FuchsJosé Barrueco
Oct 24, 2008·The New England Journal of Medicine·Christos S KarapetisJohn R Zalcberg
Jul 29, 2009·Interactive Cardiovascular and Thoracic Surgery·Ryo MaedaYuji Kawasaki
Jun 5, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Joachim PfannschmidtHendrick Dienemann
Oct 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carmen J AllegraNorman Wolmark
May 13, 2011·Thorax·Tom TreasureVern Farewell
Jun 8, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy J PriceNiall C Tebbutt
Mar 1, 2012·World Journal of Gastroenterology : WJG·Omer Fatih OlmezCengiz Gebitekin
May 2, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S SalahB Al-Haj Ali
Jul 4, 2012·Surgical Oncology·José Francisco Corona-CruzOscar Arrieta
Nov 24, 2012·PloS One·Eduardo Díaz-RubioUNKNOWN Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD)
Apr 25, 2013·Interactive Cardiovascular and Thoracic Surgery·Sukki ChoSanghoon Jheon

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Citations

May 24, 2019·Expert Review of Respiratory Medicine·Letizia ProcaccioFotios Loupakis

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