PMID: 3383946Mar 1, 1988Paper

Adjuvant systemic treatment and the pattern of recurrences in patients with breast cancer

European Journal of Cancer & Clinical Oncology
C KambyK Zedeler

Abstract

The aim was to analyze the impact of adjuvant systemic treatment (AST) on the anatomical distribution, the number, and the temporal relationship of the first metastases in 635 patients (pts) with breast cancer. These patients participated in the prospective studies of AST of the Danish Breast Cancer Cooperative Group (DBCG) 77-program. All patients had primary high-risk breast cancer (i.e. node positive or local invasion or tumor size greater than 5 cm). The initial treatment was mastectomy with axillary sampling, followed by postoperative radiotherapy. The types of AST and the number of patients with recurrence were: chemotherapy (CT), 134 pts; levamisole (LEV), 96 pts; tamoxifen (TAM), 154 pts. The pattern of recurrence in these patients was compared with the pattern of recurrence in 251 pts who did not receive AST (controls). Although CT reduced the total number of metastatic sites (P = 0.04), the incidence of liver metastases was increased compared to untreated controls (P = 0.02). The median number of metastatic sites was equal in TAM- and LEV-treated pts compared to controls. The incidence of lung metastases was increased in TAM-treated pts (P = 0.03), and LEV-treated pts had a decreased incidence of lymph node (P = 0.01)...Continue Reading

References

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Dec 1, 1987·European Journal of Cancer & Clinical Oncology·C KambyK Zedeler
Jan 1, 1986·Breast Cancer Research and Treatment·C Kamby, C Rose
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Dec 23, 1982·The New England Journal of Medicine·A R Feinstein, R I Horwitz

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Citations

Jul 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Boogerd
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R D RubensR Paridaens
May 18, 2000·Cancer Treatment Reviews·D YipP G Harper

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