PMID: 6403101Mar 12, 1983Paper

Adjuvant tamoxifen for operable carcinoma of the breast: report of clinical trial by the Christie Hospital and Holt Radium Institute

British Medical Journal
G Ribeiro, M K Palmer

Abstract

A large controlled clinical trial with the admission of 1005 patients was carried out using tamoxifen as adjuvant treatment for women with operable carcinoma of the breast. Results were analysed for the first 906 evaluable patients randomised up to December 1981. After mastectomy premenopausal women were randomised to receive either an irradiation menopause or tamoxifen 20 mg daily for one year. Postmenopausal women were randomised to receive either tamoxifen 20 mg daily for one year or no systemic treatment (controls). Analysis at five years suggested that for premenopausal women there was no significant difference between an irradiation menopause and tamoxifen in terms of survival, local recurrence, or distant metastases. Tamoxifen had no appreciable side effects. For postmenopausal women there was a trend in favour of tamoxifen with regard to survival and incidence of distant metastases, and the difference became statistically significant for those patients with four or more positive axillary nodes. If long term results of these studies show only an improved quality of remaining life with tamoxifen, then this drug could be an important contribution to adjuvant treatment.

References

Feb 1, 1976·The Journal of Endocrinology·V C Jordan, L J Dowse
Sep 1, 1978·Cancer Treatment Reviews·H MouridsenL Battersby

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Citations

Jan 1, 1986·Breast Cancer Research and Treatment·T DelozierE de Ranieri
Jan 1, 1984·Pharmacology & Therapeutics·B J Furr, V C Jordan
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·D F GibsonV C Jordan
May 28, 1983·Lancet
Jan 11, 1986·Lancet·J CuzickR D Bulbrook
Mar 25, 2014·Endocrine-related Cancer·V Craig Jordan
Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·V C JordanW V Welshons
Dec 11, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V Craig Jordan
Mar 1, 1986·European Journal of Cancer & Clinical Oncology·J L Grem, P P Carbone
Nov 1, 1994·Cancer·L G FordB S Kramer
Mar 11, 2017·Expert Review of Anticancer Therapy·Poulomi BhattacharyaV Craig Jordan
May 1, 1992·Current Problems in Cancer·V C Jordan
Aug 1, 1985·European Journal of Cancer & Clinical Oncology·G Ribeiro, R Swindell
Feb 1, 1989·The Australian and New Zealand Journal of Surgery·G Morgan, D Berg
Jan 17, 2020·Current Medical Research and Opinion·Antonio Martínez Francés, Javier Leal Martínez-Bujanda
Feb 18, 1988·The New England Journal of Medicine·M N LevineS De Pauw
Jul 1, 1983·Scottish Medical Journal·A P Forrest, R A Hawkins
Jun 1, 1985·Postgraduate Medicine·T C Gau

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