Adjuvant therapy following resection for pancreatic adenocarcinoma

Surgical Oncology Clinics of North America
Murray F Brennan

Abstract

Pancreatic adenocarcinoma remains a lethal disease. Approximately 10% to 15% of patients who are able to undergo resection will be alive at 5 years, but most of those will have late recurrence and ultimately die of the disease. Multiple adjuvant treatments have been tested, including extended operations, chemotherapy, radiation therapy, and immunotherapy--the vast majority with minimal, if any, effect. There is a small suggested benefit from adjuvant chemotherapy but little other cause for optimism. At the current time, given the relative failure of standard adjuvant approaches, it is reasonable to suggest that all patients should have tissue harvested for molecular markers and enter into investigative regimens.

References

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Citations

Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cristina R FerroneAndrew L Warshaw
Aug 2, 2007·Annals of Surgery·Karl Y BilimoriaMark S Talamonti
Dec 2, 2015·Experimental and Therapeutic Medicine·Lei DaiJeff X Zhou
Nov 13, 2012·American Journal of Surgery·John E MullinaxAlexander S Rosemurgy
Jan 21, 2009·European Journal of Radiology·Xiao Ming ZhangAgnes Witkiewicz
Sep 3, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vincenzo ValentiniGiuseppe R D'Agostino
Oct 16, 2007·American Journal of Surgery·Karl Y BilimoriaMark S Talamonti
Feb 28, 2007·Journal of the American College of Surgeons·Thomas A AloiaPeter W T Pisters
Nov 29, 2005·Obstetrics and Gynecology Clinics of North America·Jeffrey C DunkelbergJohn Deutsch

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