PMID: 9161800Mar 1, 1997Paper

Adjuvant therapy for melanoma

Current Opinion in Oncology
V K Sondak, J A Wolfe

Abstract

The search for effective adjuvant therapy for melanoma has resulted in the testing of a remarkably broad spectrum of therapeutic agents. Until recently, there was little evidence to suggest a benefit for any adjuvant therapy. The demonstration of activity for adjuvant high-dose interferon alfa in a cooperative group trial resulted in Food and Drug Administration approval and has dramatically changed the melanoma landscape. This article reviews all the randomized adjuvant trials conducted to date in melanoma, discusses pertinent studies still in progress or awaiting analysis, and offers recommendations for the adjuvant treatment of melanoma patients rendered clinically disease-free by surgery.

Citations

Apr 28, 1999·Journal of Surgical Oncology·M R Hemmila, A E Chang
Apr 30, 2003·Current Treatment Options in Oncology·Alicia TerandoVernon K Sondak
Oct 2, 2001·Pharmacology & Therapeutics·M LeszczynieckaP B Fisher
Jun 6, 2000·Advanced Drug Delivery Reviews·J E Talmadge
Nov 30, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J L González-LarribaJ Toribio
Mar 14, 2003·Critical Reviews in Oncology/hematology·Timothy M Pawlik, Vernon K Sondak
Apr 4, 2000·Oral Oncology·M J Hicks, C M Flaitz
Sep 25, 2001·The Laryngoscope·E J Lentsch, J N Myers
May 16, 2000·Plastic and Reconstructive Surgery·J D WagnerJ J Coleman
Apr 28, 2004·American Journal of Clinical Dermatology·Noah ScheinfeldJeffrey M Weinberg
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·H M HortonS E Parker
May 6, 2005·Journal of Lower Genital Tract Disease·Mary Ellen WechterTimothy M Johnson
Apr 6, 2004·Surgical Oncology Clinics of North America·Maher N Younes, Jeffrey N Myers
Dec 23, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Q LiA E Chang
Oct 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter HerseyR John Simes
Jul 13, 2002·Expert Review of Anticancer Therapy·V K Sondak
Apr 28, 2001·Annals of Plastic Surgery·R ZuckermanE K Mooney
Oct 7, 2004·Pediatric Blood & Cancer·Mwe Mwe ChaoJames A Williams
Apr 24, 2019·Journal of Medical Economics·Arielle G BensimonRaquel Aguiar-Ibáñez
Oct 12, 2001·Melanoma Research·R A CahillH P Redmond
May 20, 2000·Annals of the New York Academy of Sciences·T NakayamaD S Hoon
Jul 21, 1998·Seminars in Cutaneous Medicine and Surgery·I H Olhoffer, J L Bolognia
Aug 24, 1999·Annals of Surgical Oncology·K M McMastersM I Ross

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