Adjuvant therapy for resectable rectal and colonic cancer

The British Journal of Surgery
A G Heriot, D Kumar

Abstract

Recurrence of rectal and colonic carcinoma remains substantial despite apparently curative surgery. Adjuvant therapy has been applied to improve prognosis. This review evaluates the use of adjuvant therapy in the management of resectable rectal and colonic carcinoma. It assesses critically the evidence supporting the addition of radiotherapy, chemotherapy, chemoradiotherapy and other treatment modalities to optimal surgery. In the case of rectal tumours, preoperative is more effective than postoperative radiotherapy; It can significantly reduce the incidence of local tumour recurrence. A number of trials have tended towards showing a survival advantage and a recent large randomized trial has shown a significant improvement in survival in patients with Dukes C tumours. Postoperative chemoradiotherapy is associated with a survival benefit and is standard therapy in the USA, although it is associated with increased toxicity. The effectiveness of preoperative chemoradiotherapy is currently being investigated. Postoperative fluorouracil-containing chemotherapy has resulted in a survival advantage in patients with Dukes C colonic tumours; such therapy may be administered either systemically or intraportally. The evidence of benefit w...Continue Reading

References

Sep 1, 1979·The British Journal of Surgery·R J NichollsA G Parks
Sep 1, 1975·Archives of Surgery·S N FainL Morgenstern
Jul 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P RougierD Gallot
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Nov 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H C StevensonD R Parkinson
Mar 14, 1991·The New England Journal of Medicine·J E KrookJ A Mailliard
May 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C G WillettW C Wood
Mar 1, 1991·The British Journal of Surgery·A R DixonJ T Holmes
Feb 8, 1990·The New England Journal of Medicine·C G MoertelJ H Glick
May 1, 1990·The British Journal of Surgery·N D KaranjiaR J Heald
Jan 1, 1989·CA: a Cancer Journal for Clinicians·M H Myers, L A Ries
Jun 6, 1985·The New England Journal of Medicine·UNKNOWN Gastrointestinal Tumor Study Group
Dec 1, 1988·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P R Thomas, A S Lindblad
Oct 1, 1988·The British Journal of Surgery·P J HoldsworthP Quirke
Mar 2, 1988·Journal of the National Cancer Institute·N WolmarkW Lawrence
Jun 24, 1988·JAMA : the Journal of the American Medical Association·M BuyseT C Chalmers
Jan 1, 1987·Diseases of the Colon and Rectum·R NevilleC Amendola
Nov 13, 1986·The New England Journal of Medicine·H O DouglassUNKNOWN Gastrointestinal Tumor Study Group
Jan 1, 1984·The British Journal of Surgery·R K PhillipsL P Fielding
Mar 15, 1984·Cancer·G H Fletcher

❮ Previous
Next ❯

Citations

Jun 12, 1999·American Journal of Surgery·S F CounterM J Hart
Aug 11, 2000·Critical Reviews in Oncology/hematology·F Di CostanzoS Gasperoni
Aug 10, 1999·Critical Reviews in Oncology/hematology·A ZaniboniG Morandi
Aug 23, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Ponz de LeonL Roncucci
Jul 23, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F Bonino, P Conte
Jul 23, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G Di StefanoL Fiume
Aug 17, 2000·The Australian and New Zealand Journal of Surgery·G StevensR West
Jan 1, 2000·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland· Gandy Roe
May 1, 2000·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland· Heriot, Kumar
Mar 6, 1998·Annals of Surgery·G A PorterS C Newman
Feb 8, 2011·American Journal of Clinical Oncology·Hsuan Chih HsuEng Yen Huang
Oct 13, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A G HeriotJ Mackay
May 15, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E MacDermidC Porteous
Dec 14, 2011·Journal of Cardiothoracic Surgery·Abidin SehitogullariAli Kahraman
Apr 30, 2014·Expert Opinion on Drug Delivery·Luigi FiumeGiuseppina Di Stefano
Nov 27, 1998·Acta Oncologica·N Wilking
Mar 17, 1999·Annals of Surgery·A Renehan, S T O'Dwyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.