Adjuvant therapy in major salivary gland cancers: Analysis of 8580 patients in the National Cancer Database

Head & Neck
Shayan CheraghlouBenjamin L Judson

Abstract

Evidence surrounding the effect of adjuvant treatment in salivary gland cancers is limited. The benefit of adding chemotherapy to adjuvant treatment is also of interest. We investigated the association of these treatments with survival and whether this differed by stage or the presence of adverse features. A retrospective study of adult salivary gland cancer cases diagnosed from 2004 to 2013 in the National Cancer Data Base (NCDB) was conducted. Treatment with adjuvant radiotherapy was associated with improved survival for both patients with early-stage (hazard ratio [HR] 0.744; P = .004) and late-stage (HR 0.688; P < .001) disease with adverse features. Further addition of chemotherapy to the adjuvant treatment of patients with late-stage disease with adverse features was not associated with a survival benefit (HR 1.028; P = .705). Adjuvant radiotherapy is associated with improved survival for patients with adverse features, regardless of stage. The addition of chemotherapy to the adjuvant treatment of patients with late-stage disease with adverse features is not associated with improved outcomes.

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Citations

Aug 29, 2018·The Laryngoscope·Shayan CheraghlouBenjamin L Judson
Jan 31, 2019·The Laryngoscope·Craig A Bollig, Robert P Zitsch
Feb 6, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Katri AroZachary S Zumsteg
Mar 13, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jamie OliverBabak Givi
Apr 21, 2020·The Oncologist·Glenn J HannaNicole G Chau
Aug 14, 2019·International Journal of Radiation Oncology, Biology, Physics·Neil B NewmanLisa A Kachnic
Oct 24, 2019·Cancer Treatment Reviews·Gerben LasscheCarla M L van Herpen
Feb 10, 2021·Current Treatment Options in Oncology·Nikhil P Joshi, James R Broughman
Apr 27, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jessica L GeigerPatrick Ha
Jul 15, 2021·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Akshat MalikAlasdair Mace

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