Adjuvant Therapy Is Associated With Improved Survival in Resected Perihilar Cholangiocarcinoma: A Propensity Matched Study

Annals of Surgical Oncology
Ibrahim NassourAdam C Yopp

Abstract

There are limited well-controlled studies that conclusively demonstrate a benefit of adjuvant therapy in resected perihilar cholangiocarcinoma. Most studies include all biliary tract tumors as one entity despite the heterogeneity of these diseases. We identified patients with resected perihilar cholangiocarcinoma from the National Cancer Database between 2006 and 2013. Patients who received adjuvant therapy (AT) were compared to an observation (OB) cohort by propensity score matching. We identified 1846 patients: 1053 patients (57%) in the OB group, and 793 (43%) in the AT group. Patients who received adjuvant therapy were more likely to be younger, have a higher rate of private insurance, have higher T and N stage tumors, and were more likely to have positive resection margins. After 1:1 propensity score matching, 577 OB group patients were compared with 577 AT group patients. The AT cohort was associated with better overall survival compared with the OB cohort (hazard ratio [HR] 0.73; 95% confidence interval [CI] 0.64-0.83). The median survival was 29.5 and 23.3 months for the AT and OB groups, respectively (P < 0.01). Subgroup analysis demonstrated a survival advantage for adjuvant therapy in disease with positive resection ...Continue Reading

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Citations

Dec 12, 2018·Journal of Oncology Practice·Anne M Horgan, Jennifer J Knox
Mar 12, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rachna T ShroffShishir K Maithel
Aug 4, 2020·World Journal of Gastroenterology : WJG·Daniele DondossolaDiego Foschi
Aug 15, 2021·Clinics and Research in Hepatology and Gastroenterology·Shaoming SongTiankang Guo
Sep 3, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kyubo KimEui Kyu Chie
Sep 14, 2021·The Cochrane Database of Systematic Reviews·Vor LuviraPorjai Pattanittum

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