Adjuvant treatment for patients with FIGO stage I uterine serous carcinoma confined to the endometrium.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Dimitrios NasioudisNawar A Latif

Abstract

The role of adjuvant treatment for early-stage uterine serous carcinoma is not defined. The goal of this study was to investigate the impact of adjuvant treatment on survival of patients with tumors confined to the endometrium. Patients diagnosed with stage I uterine serous carcinoma with no myometrial invasion between January 2004 and December 2015 who underwent hysterectomy with at least 10 lymph nodes removed were identified from the National Cancer Database. Adjuvant treatment patterns defined as receipt of chemotherapy and/or radiotherapy within 6 months from surgery were investigated and overall survival was evaluated using Kaplan-Meier curves, and compared with the log-rank test for patients with at least one month of follow-up. A Cox analysis was performed to control for confounders. A total of 1709 patients were identified; 833 (48.7%) did not receive adjuvant treatment, 348 (20.4%) received both chemotherapy and radiotherapy, 353 (20.7%) received chemotherapy only, and 175 (10.2%) received radiotherapy only. Five-year overall survival rates for patients who did not receive adjuvant treatment (n=736) was 81.9%, compared with 91.3% for those who had chemoradiation (n=293), 85.1% for those who received radiotherapy only ...Continue Reading

References

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Nov 14, 2019·Cancers·Pooja PanditaShannon M Hawkins

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Citations

Jul 22, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jennifer Mueller, Vicky Makker
Oct 22, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Anne Sophie V M van den HeerikCarien L Creutzberg
May 4, 2021·Gynecologic Oncology·Giorgio BoganiBradley J Monk
Jul 16, 2021·Current Opinion in Oncology·Ane Gerda Z Eriksson, Jennifer J Mueller
Aug 24, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Hsiu-Jung TungChyong-Huey Lai

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