Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas

The Cochrane Database of Systematic Reviews
H Quon, B Abdulkarim

Abstract

AO and AOA are known to be chemosensitive tumors. However, the impact of adding chemotherapy to surgery and radiotherapy has not been studied. Also, the value of chromosome 1p and 19q deletions as prognostic and predictive markers is only beginning to be defined. After surgery, to compare radiotherapy (RT) plus chemotherapy versus RT alone (standard of care) in adults with newly diagnosed AO or mixed AOA. To investigate the prognostic and predictive value of loss of heterozygosity of chromosomes 1p and 19q. Outcomes analyzed include overall survival (OS), progression-free survival (PFS), and treatment toxicity greater than or equal to grade 3. Cochrane Central Register for Controlled Trials (CENTRAL, Issue 4,2006), MEDLINE (1966 to 2006) and EMBASE (1988 to 2006) were searched. Reference lists from relevant studies were scanned for any additional relevant articles. RCTs of adults with AO or mixed AOA comparing surgery plus RT versus surgery plus RT plus chemotherapy were included. No specific chemotherapy regimens were excluded. Relevant studies were critically appraised and data was extracted. Based on the differences in patient selection with respect to the definition of AO (2 versus 3 high risk anaplastic features) and seque...Continue Reading

Citations

Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lynette M MooreWei Zhang
Oct 22, 2013·Radiation and Environmental Biophysics·Michael OrthClaus Belka
Aug 13, 2011·Brain Tumor Pathology·Edward A MonacoJohnathan A Engh
Oct 17, 2012·Médecine sciences : M/S·Maïté VerreaultAhmed Idbaih
Jan 3, 2013·Asia-Pacific Journal of Clinical Oncology·Chee Kian ThamEu Tiong Chua
May 17, 2014·The Cochrane Database of Systematic Reviews·Magali Lecavalier-BarsoumBassam Abdulkarim

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