Adjuvant treatment of stage I lung cancer with high-dose vitamin A

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
U PastorinoM Valente

Abstract

Vitamin A and retinoids are strong inhibitors of epithelial cancer promotion and progression in experimental carcinogenesis. This study examined whether they may prevent the occurrence of upper aerodigestive cancer in subjects heavily exposed to tobacco smoking, such as patients already cured of an early-stage lung cancer. The adjuvant effect of high-dose vitamin A was tested on 307 patients with stage I non-small-cell lung cancer. After curative surgery, patients were randomly assigned to either a group prescribed retinol palmitate administration (orally 300,000 IU daily for 12 months) or a control group prescribed no treatment. After a median follow-up of 46 months, the number of patients with either recurrence or new primary tumors was 56 (37%) in the treated arm and 75 (48%) in the control arm. Eighteen patients in the treated group developed a second primary tumor, and 29 patients in the control group developed 33 second primary tumors. A statistically significant difference in favor of treatment was observed concerning time to new primary tumors in the field of prevention (P = .045, log-rank test). The treatment difference in terms of disease-free interval was close to statistical significance (P = .054, log-rank test) an...Continue Reading

Citations

Nov 1, 1994·European Journal of Cancer. Part B, Oral Oncology·N de VriesN van Zandwijk
Dec 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·N van Zandwijk
Jul 18, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·W Jeffrey PettyEthan Dmitrovsky
Sep 27, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Steven M KellerUNKNOWN Eastern Cooperative Oncology Group
Nov 13, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Nico van Zandwijk, Fred R Hirsch
Jun 19, 1998·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M Zwitter, J S Tobias
Jun 1, 1997·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F A Shepherd
Nov 1, 1996·Seminars in Oncology Nursing·N L Risser
Apr 8, 1998·Nutrition·K N PrasadP Hovland
Apr 14, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Decensi, A Costa
Mar 13, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U Pastorino
Nov 1, 1996·European Journal of Cancer. Part B, Oral Oncology·R JyothirmayiR Sankaranarayanan
Feb 14, 2002·Critical Reviews in Oncology/hematology·Shi-Yong Sun, Reuben Lotan
May 8, 1998·Critical Reviews in Oncology/hematology·L RepettoM Aapro
May 2, 2000·Critical Reviews in Oncology/hematology·G E Goodman
Aug 9, 2002·Oral Oncology·Ingeborg Klaassen, Boudewijn J M Braakhuis
Nov 7, 2003·The Lancet Oncology·Jean-Charles SoriaWaun Ki Hong
Nov 12, 2003·Clinical Lung Cancer·Angelia D Gibson
Jan 8, 2004·Seminars in Thoracic and Cardiovascular Surgery·Daniel D KarpEdward S Kim
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·J LangenfeldE Dmitrovsky
Dec 1, 1998·Pathology International·K HiroshimaT Fujisawa
Jul 27, 2001·Postgraduate Medical Journal·R A SharmaW P Steward
Jul 16, 2008·Journal of Experimental & Clinical Cancer Research : CR·Krisztina BogosBalazs Dome
Jan 14, 2009·Cancer Prevention Research·Sarah J FreemantleEthan Dmitrovsky
Jul 9, 2009·Cancer Prevention Research·Yian WangMing You
Jan 17, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roisin M ConnollySaraswati Sukumar
Dec 30, 2014·Molecular Aspects of Medicine·Alessandra di MasiClara Nervi
Jul 28, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fadlo R Khuri, Reuben Lotan
Jul 28, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jin Seuk KimDuk-Hwan Kim
Aug 1, 1993·Cancer·S M LippmanW K Hong
Nov 14, 2015·Critical Reviews in Food Science and Nutrition·Shimrit Bar-El Dadon, Ram Reifen
Jan 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·N MartiniR J Ginsberg
Nov 1, 1994·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·U Pastorino
Nov 1, 1994·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S E BennerW K Hong
Aug 10, 2005·Current Problems in Surgery·Alexander Sasha KrupnickBryan Meyers
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S E BennerW K Hong
Jul 1, 2005·Seminars in Oncology·Noel R Wardwell, Pierre P Massion

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.