PMID: 6105336Jul 26, 1980Paper

Adjuvant treatment with polyadenylic-polyuridylic acid (Polya.Polyu) in operable breast cancer

Lancet
J LacourJ Viguier

Abstract

Adjuvant immunotherapy with polyadenylic-polyuridylic acid (PolyA.PolyU) was tested in a randomised trial on 300 patients with operable breast cancer, all of whom were treated by surgery with or without radiotherapy. They were randomly divided into an experimental group of 155 patients who were treated with 30 mg PolyA.PolyU intravenously per week for 6 weeks and a control group of 145 patients who received normal saline intravenously on the same schedule. The mean follow-up time was more than 50 months in both groups. The overall survival was significantly higher in the treated group (p less than or equal to 0.05), in whom the 5-year "relapse-free" surival was also increased. In node-positive patients, treatment increased the relapse-free survival (p less than or equal to 0.03) and overall survival (p less than or equal to 0.07). No side-effects were noted. Thus, immunotherapy with PolyA.PolyU appears to be a simple, non-toxic, and efficient adjuvant treatment in operable breast cancer.

References

Aug 11, 1979·Lancet·R W Blamey
Feb 19, 1976·The New England Journal of Medicine·G BonadonnaU Veronesi

❮ Previous
Next ❯

Citations

Jan 1, 1985·Springer Seminars in Immunopathology·A G Johnson, J Regal
Nov 1, 1986·European Journal of Cancer & Clinical Oncology·J L Haybittle
Feb 1, 1992·AIDS Research and Human Retroviruses·A G Laurent-CrawfordA G Hovanessian
Nov 1, 1993·AIDS Research and Human Retroviruses·B KrustA G Hovanessian
Apr 26, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Danielle N VanJessica K Bell
Mar 12, 2013·Journal of Leukocyte Biology·Sabina KaczanowskaEduardo Davila
Jan 1, 1994·Cancer Investigation·R C Turowski, P L Triozzi
Mar 15, 2012·Expert Opinion on Biological Therapy·Stephen E Wright
Aug 31, 2012·Oncoimmunology·Lorenzo GalluzziGuido Kroemer
Apr 15, 2017·Apoptosis : an International Journal on Programmed Cell Death·Ana R BernardoAna M Jiménez-Lara
Oct 21, 2010·Annals of the New York Academy of Sciences·Clara LocherLaurence Zitvogel
Mar 1, 1992·World Journal of Surgery·W H McCarthyF Belli
Apr 22, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F AndreM Cristofanilli
Feb 26, 2016·Nature Reviews. Cancer·Belinda S ParkerPaul J Hertzog
Apr 25, 2012·World Journal of Gastrointestinal Surgery·Noemí Eiró, Francisco J Vizoso
May 1, 1993·Stem Cells·G H Heppner
Dec 15, 2016·Frontiers in Immunology·Tomomi ToubaiPavan Reddy
Apr 5, 2013·Journal of Cellular and Molecular Medicine·Guido GambaraAnna Riccioli
Nov 6, 2007·International Immunology·Takahiro SugiyamaTsuneyasu Kaisho
Sep 17, 2020·Oncoimmunology·Julie Le NaourErika Vacchelli
Jul 1, 1994·Clinical Microbiology Reviews·A G Johnson
Sep 30, 2021·Chemical Communications : Chem Comm·Daria V Berdnikova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.