Adjuvanticity of aluminium hydroxide and calcium phosphate in diphtheria-tetanus vaccines--I

Vaccine
H Aggerbeck, I Heron

Abstract

The potencies of two diphtheria-tetanus vaccines (DT) adsorbed to either aluminium hydroxide or calcium phosphate were compared in mice and guinea pigs. The vaccines were made from the same batches of purified toxoids and contained the same amounts of antigens. Immunizations were done once or twice with different doses of vaccine injected undiluted, diluted in saline or diluted in the corresponding adjuvant. The various potency assays showed that the adjuvanticity of calcium phosphate was lower than or equal to aluminium hydroxide. Despite the range of potency assays done, none of the methods reflected the efficacy of these vaccines in revaccination of humans. A simplified potency assay is suggested for release of final vaccine formulations to reduce the number of animals in quality control.

References

Oct 1, 1991·Biologicals : Journal of the International Association of Biological Standardization·J Lyng, I Heron
Apr 1, 1991·Biologicals : Journal of the International Association of Biological Standardization·H Aggerbeck, I Heron
Jan 1, 1990·Biologicals : Journal of the International Association of Biological Standardization·J LyngL Ljungqvist
Jul 1, 1986·Journal of Biological Standardization·O SimonsenI Heron
Jul 1, 1942·American Journal of Public Health and the Nation's Health·V K Volk, W E Bunney

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·R K Gupta
Dec 17, 2014·The Journal of Pharmacy and Pharmacology·Charlotte N MaughanGareth R Williams
Apr 11, 2015·Immunopharmacology and Immunotoxicology·Ozgur KartalOsman Sener
Jan 24, 2007·Vaccine·Morten Thaysen-AndersenPeter Højrup
Oct 4, 2016·Expert Review of Vaccines·Jean-Daniel MassonGuillemette Crépeaux
Jun 19, 2018·Chemical Society Reviews·Xia LiAtsuo Ito
Jun 16, 2017·Viral Immunology·Yulia BurakovaJishu Shi
Oct 30, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Jan NilssonPrediman K Shah

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