PMID: 9554280Apr 29, 1998Paper

Adjuvants in perspective

Developments in Biological Standardization
F R Vogel

Abstract

Many vaccines currently under development and testing are composed of synthetic, recombinant, or highly purified subunit antigens. Vaccines composed of these subunit antigens are often considered to be safer than whole-inactivated or live-attenuated vaccines. However, vaccines containing purified subunit antigens are often less immunogenic than traditional vaccines. Immunological adjuvants are agents that enhance specific immune responses to vaccines. Formulation of vaccines with potent adjuvants is an attractive approach for enhancing immune responses to subunit antigens. Adjuvants have diverse mechanisms of action and should be selected for use based on the route of administration and the type of immune response (antibody, cell-mediated, or mucosal) desired for a particular vaccine. Adjuvant mechanisms of action include: (i) increasing the biological or immunological half-life of vaccine antigens; (ii) improving antigen delivery and presentation; and (iii) inducing the production of immunomodulatory cytokines. Through modulation of cytokine responses, adjuvant formulations can be designed that favour the development of Th1 (type 1) or Th2 (type 2) immune responses to vaccine antigens. Novel adjuvants are currently undergoing ...Continue Reading

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
F R Vogel
International Journal of Immunopharmacology
F R Vogel
The Indian Journal of Medical Research
Teena MohanD Nageswara Rao
Current Topics in Microbiology and Immunology
K Schneider-Ohrum, Ted M Ross
© 2022 Meta ULC. All rights reserved