Administration frequency as well as dosage of PTH are associated with development of cortical porosity in ovariectomized rats

Bone Research
Aya TakakuraTadahiro Iimura

Abstract

To investigate whether the administration frequency of parathyroid hormone (PTH) is associated with the development of cortical porosity, this study established 15 dosage regimens of teriparatide [human PTH(1-34), TPTD] with four distinct concentrations and four distinct administration frequencies of TPTD to 16-week-old ovariectomized rats. Our analyses demonstrated that the bone mineral density, mechanical properties, and bone turnover were associated with the total amount of TPTD administered. Our observations further revealed that the cortical porosity was markedly developed as a result of an increased administration frequency with a lower concentration of total TPTD administration in our setting, although the highest concentration also induced cortical porosity. Deconvolution fluorescence tiling imaging on calcein-labeled undecalcified bone sections also demonstrated the development of cortical porosity to be closely associated with the bone site where periosteal bone formation took place. This site-specific cortical porosity involved intracortical bone resorption and an increased number and proximity of osteocytic lacunae, occasionally causing fused lacunae. Taken together, these findings suggested the involvement of local...Continue Reading

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Citations

Jan 13, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Bo Yoon ChangSung Yeon Kim
Aug 9, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T SugimotoT Nakamura
Jul 6, 2020·Biomechanics and Modeling in Mechanobiology·Mehran AshrafiManuel Doblaré
Aug 8, 2019·Journal of Biomaterials Applications·Hiroshi KumagaiMasashi Yamazaki
Jul 16, 2020·International Journal of Molecular Sciences·Linda SequeiraAnja Nohe
Nov 12, 2020·BMC Oral Health·Jiyeon KimMin-Ji Kim
May 19, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H HaginoS Mori

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Methods Mentioned

BETA
ELISA
X-ray
fluorescence imaging

Software Mentioned

TRAPEZIUM2
OsteoMeasure
elements
- BON
TRI
NIS
3D

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