PMID: 9420212Jan 7, 1998Paper

Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques

Journal of Virology
T MatanoM A Martin

Abstract

Parenteral administration of a mouse anti-human CD8 monoclonal antibody (MAb) to rhesus macaques resulted in a transient depletion of CD8+ cells in both the peripheral blood and lymphoid tissues. When administered during primary chimeric simian/human immunodeficiency virus infections, the CD8 MAb caused marked elevations of plasma and cell-associated virus levels in both the peripheral blood and lymphoid tissues and led to prolonged depletion of CD4 cells. Taken together, these results directly demonstrate that CD8+ T lymphocytes are actively involved in controlling the acute phase of primate lentivirus infections.

References

Jul 7, 1983·The New England Journal of Medicine·A J McMichaelP A Beare
Oct 1, 1993·Clinical Immunology and Immunopathology·A L LandayJ A Levy

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Citations

Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J C Gea-BanaclocheM Connors
May 11, 2002·Nature Reviews. Immunology·Andrew McMichael, Tomâs Hanke
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zdenek HelGenoveffa Franchini
Jun 24, 2004·The Journal of Experimental Medicine·Tetsuro MatanoYoshiyuki Nagai
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·John T LoffredoDavid I Watkins
Jul 29, 2006·Journal of Medical Primatology·Joseph J MattapallilMario Roederer
Jan 26, 2007·Journal of Virology·Thomas C FriedrichDavid I Watkins
Jun 21, 2007·PloS One·Hiroyuki YamamotoTetsuro Matano
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ashley P BarryMark B Feinberg
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marjon NavisHanneke Schuitemaker
Apr 18, 2008·Reviews in Medical Virology·Hiroyuki Yamamoto, Tetsuro Matano
Feb 12, 2008·Statistics in Medicine·W David Wick
Feb 10, 2009·Journal of Medical Primatology·Guido Silvestri
Jul 1, 2006·Current Opinion in HIV and AIDS·Joseph J Mattapallil, Mario Roederer
Nov 23, 2010·AIDS Research and Human Retroviruses·Otto O YangBeth D Jamieson
May 25, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Santhi GorantlaLarisa Y Poluektova
Dec 21, 2010·Immunologic Research·Stephanie A FreelGeorgia D Tomaras
Nov 30, 2011·PLoS Computational Biology·Andrew J YatesRustom Antia

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