Administration of an antiprogesterone up-regulates estrogen receptors in the endometrium of women using Norplant: a pilot study

Fertility and Sterility
A F GlasierHilary O D Critchley


To determine the effect of a single dose of mifepristone (200 mg) on endometrial estrogen and progesterone receptors in Norplant users. A prospective single-blind placebo-controlled pilot study. SETTING; Women were recruited from a large family planning clinic and were studied either at the clinic or in a clinical research unit attached to a teaching hospital gynecology department. Eight women using Norplant and experiencing vaginal bleeding more often than once every 24 days. All completed the study. Endometrial biopsies were taken after treatment with both placebo and 200 mg of mifepristone, both given at the start of a bleeding episode. Expression of endometrial progesterone (PR) and estrogen (ER) receptors, ovulation, and vaginal bleeding. Mifepristone administration was associated with down-regulation of PR receptor subtype B and up-regulation of ER. Women treated with mifepristone showed a tendency to increased ovulation rates and reduced vaginal bleeding. The effect of mifepristone on endometrial steroid receptors was consistent with functional inhibition of progesterone. The findings warrant further investigation of this regimen as a strategy to reduce frequent bleeding.


Oct 1, 1996·Human Reproduction·J K Findlay
Feb 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·R K MangalN L Weigel
Apr 29, 1998·Contraception·I S FraserI Sivin
Jun 10, 1998·Molecular Human Reproduction·H WangD T Baird
Jun 5, 1999·Science·B R BloomJ D Sachs

❮ Previous
Next ❯


Aug 10, 2004·Archives of Gynecology and Obstetrics·Samhita ChakrabortyK Uma Chaturvedi
Oct 18, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R Varma, L Mascarenhas
Jun 25, 2005·Current Opinion in Obstetrics & Gynecology·Julia Osei, Hilary Critchley
May 24, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Naomi B MorisonLois A Salamonsen
Dec 17, 2008·Women's Health·Sophie OuzounianNathalie Chabbert-Buffet
Mar 15, 2012·Molecular and Cellular Endocrinology·Nathalie Chabbert-BuffetPhilippe Bouchard
Mar 13, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Suman LalNutan Agarwal
Apr 25, 2008·Trends in Endocrinology and Metabolism : TEM·Martha Hickey, Lois A Salamonsen
Jun 22, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mario LapecorellaGuglielmo Mariani
Apr 22, 2010·The Journal of Family Planning and Reproductive Health Care·Julia Wilkens, Hilary Critchley
Dec 21, 2018·Archives of Gynecology and Obstetrics·Feng ZhouLili Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.