Administration of an Oral Hydration Solution Prevents Electrolyte and Fluid Disturbances and Reduces Readmissions in Patients With a Diverting Ileostomy After Colorectal Surgery: A Prospective, Randomized, Controlled Trial

Diseases of the Colon and Rectum
Athanasios MigdanisGeorgios Tzovaras

Abstract

Patients with a newly formed ileostomy often develop electrolyte abnormalities and dehydration. The study assessed the prophylactic effect of an isotonic hydration solution on dehydration and electrolyte abnormalities in patients with a newly formed ileostomy. This was a prospective, randomized, controlled trial (NCT02036346). The study was conducted at a single surgical unit of a public university hospital. Patients scheduled for elective rectosigmoid resection were considered for study inclusion. Patients in whom a diverting ileostomy was created were randomly assigned to the intervention group (n = 39), which received an oral isotonic glucose-sodium hydration solution for 40 days postdischarge and the control group (n = 41) which did not receive an intervention. The 2 groups were compared with a group of patients who underwent rectosigmoid resection without diverting ileostomy (n = 37). Serum electrolyte and renal function markers were assessed preoperatively and at 20 and 40 days postdischarge. At 20 days postdischarge, the serum sodium of the control group appeared lower than the serum sodium of the intervention group and the nonileostomy group (p = 0.007). At the same time point, urea and creatinine levels of the control ...Continue Reading

Associated Clinical Trials

References

Jun 21, 1975·British Medical Journal·G N Tytgat, K Huibregtse
Sep 27, 1990·The New England Journal of Medicine·M E Avery, J D Snyder
Apr 1, 1985·Scandinavian Journal of Gastroenterology·K Ladefoged, K Olgaard
Apr 1, 1982·The Australian and New Zealand Journal of Surgery·R F KingG L Hill
Oct 1, 1994·Physiological Reviews·M A Hediger, D B Rhoads
Jun 20, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Wolfgang J WeiseF John Gennari
Jul 17, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J Shabbir, D C Britton
Nov 6, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M L BakerJ M D Nightingale
Dec 25, 2010·International Journal of Colorectal Disease·Nicole Beck-KaltenbachBernhard Rumstadt
Jan 10, 2012·Diseases of the Colon and Rectum·Evangelos MessarisLisa S Poritz
Nov 30, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Dana M HaydenTheodore J Saclarides
Jul 17, 2014·International Journal of Colorectal Disease·Bodil GesslerEva Angenete
May 10, 2015·Nutrition Journal·Jose J Arenas VillafrancaPilar Utrilla Navarro

❮ Previous
Next ❯

Citations

Sep 29, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A FieldingA T Stearns
Apr 22, 2020·Proceedings·Kyle M Rowe, Lawrence R Schiller
Aug 28, 2020·International Journal of Environmental Research and Public Health·Georgios VasilopoulosGeorgia Fasoi
Jul 22, 2020·Diseases of the Colon and Rectum·Yu-Ting van LoonDavid D E Zimmerman
Dec 23, 2019·Surgery Today·Mizunori YaegashiAkira Sasaki
Feb 5, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Chen LiuIan Bissett

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.