Administration of anti-interleukin-6 monoclonal antibody prolongs cardiac allograft survival

Transplant International : Official Journal of the European Society for Organ Transplantation
Jun LeiZhishui Chen

Abstract

To investigate the effects of anti-IL-6 monoclonal antibody (anti-IL-6 mAb) on acute allograft rejection and the potential mechanisms in a mouse heart transplantation model. Heterotopical heart graft model was performed. The anti-IL-6 mAb was administered to recipient mice after cardiac grafting. Results were compared with administration of anti-IL-17 mAb or anti-IL-6 mAb+anti-IL-17 mAb (the 'double' treatment). The cardiac allograft survival was monitored by daily palpation in combination with histological evaluation. Quantitative polymerase chain reaction assay, mixed lymphocyte reaction, and flow cytometric analysis were employed to determine the mRNA expression of pro-inflammatory cytokines, allogeneic T-cell proliferation, and the proportion of CD4(+) CD25(+) Foxp3(+) regulatory T cells in graft-infiltrating lymphocytes and splenocytes of recipients, respectively. The results showed that the cardiac allograft survival in anti-IL-6 mAb-treated mice was prolonged significantly when compared with that of the untreated or anti-IL-17 mAb-treated mice. Meanwhile, the 'double-treated' did not prolong graft survival significantly when compared with those treated with anti-IL-6 mAb. The increase of graft survival induced by anti-IL...Continue Reading

References

Feb 1, 1990·The Biochemical Journal·P C HeinrichT Andus
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad
Jan 25, 2000·Experimental Nephrology·I ColettaC Milanese
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C A Piccirillo, E M Shevach
Jul 31, 2001·Transplantation·J L TangA W Thomson
Jul 13, 2002·The Journal of Pathology·Che-Chuan LoongChing-Yuang Lin
Aug 17, 2002·Current Opinion in Immunology·Mahzuz KarimKathryn J Wood
Nov 13, 2004·Immunity·Chandrashekhar Pasare, Ruslan Medzhitov
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adam P KohmStephen D Miller
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S YoshidaD S Wilkes
May 26, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Xiaofeng JiangKen-ichiro Seino
Jun 2, 2006·Springer Seminars in Immunopathology·Burkhard Möller, Peter M Villiger
Dec 19, 2006·Transplantation Proceedings·W LiJ D Perkins
Aug 7, 2007·Nature Immunology·Nicholas J WilsonRene de Waal Malefyt
Jun 19, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W LiJ D Perkins
Jun 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Satoshi SeradaTetsuji Naka
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bryna E BurrellD Keith Bishop
Nov 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Thomas KornMohamed Oukka
Dec 3, 2008·The Journal of Experimental Medicine·Xueli YuanM Javeed Ansari

❮ Previous
Next ❯

Citations

May 9, 2012·The Annals of Thoracic Surgery·Naoyuki KimuraMichael P Fischbein
Jan 14, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Masateru UchiyamaMasanori Niimi
Jul 30, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Stefan M BrunnerStefan Fichtner-Feigl
Feb 9, 2011·Atherosclerosis·Xiang ChengYu-Hua Liao
Mar 25, 2015·Circulation Research·Hua ShenDaniel R Goldstein
Oct 25, 2016·Transplantation·Akiko FurukawaQizhi Tang
Jun 15, 2019·Proceedings of the National Academy of Sciences of the United States of America·Nina PilatJonathan Sprent
Dec 18, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sindhu ChandranFlavio G Vincenti
Jun 9, 2021·Current Transplantation Reports·Cynthia L Miller, Joren C Madsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.