Administration of antibody to the lung protects mice against pneumonic plague.

Infection and Immunity
Jim HillR W Titball

Abstract

Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

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Apr 3, 2013·Infection and Immunity·Anthony J HickeyStephen T Smiley
May 26, 2010·Infection and Immunity·Estela M GalvánDieter M Schifferli
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Jun 3, 2021·Biomolecules·Florent Sebbane, Nadine Lemaître

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