Administration of hydrogen-rich saline in mice with allogeneic hematopoietic stem-cell transplantation

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Lijuan YuanJianming Cai

Abstract

Hydrogen, as a novel antioxidant, has been shown to selectively reduce the level of hydroxyl radicals and alleviate acute oxidative stress in many animal experiments. Hydrogen-rich saline provides a high concentration of hydrogen that can be easily and safely applied. Allogeneic hematopoietic stem-cell transplantation (HSCT) has been the most curative therapy for hematological malignancies. However, acute graft-versus-host disease (aGVHD) is the main cause of death in post-transplantation patients. In this study, we examined whether hydrogen-rich saline would show favorable effects on acute GVHD in mice. After lethal irradiation, BALB/c mice received bone marrow transplantation from C57BL/6 mice. Hydrogen-rich saline (5 ml/kg) was given to recipient mice in the hydrogen group once a day by intraperitoneal injection, and saline (5 ml/kg) was given to recipient mice in the saline group. Survival rates were monitored, clinical and pathological scores of aGVHD were determined after bone marrow transplantation (BMT), and the serum cytokine levels were examined on the 7th day after BMT. This study proves that hydrogen-rich saline increased the survival rate, reduced clinical and histopathological scores of aGVHD, promoted the recover...Continue Reading

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Citations

Oct 28, 2015·Medical Gas Research·Ryosuke KurokawaFumitake Sato
Dec 25, 2019·Oxidative Medicine and Cellular Longevity·Liren QianCiprian Tomuleasa

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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