Administration of MK-801 decreases c-Fos expression in the trigeminal sensory nuclear complex but increases it in the midbrain during experimental movement of rat molars

Brain Research
Yukiko HattoriK Tanne

Abstract

Various studies reported c-Fos expression in the neurons in the trigeminal sensory nuclear complex (TSNC) following experimental tooth movement, which implies pain transmission to the central nervous system. Meanwhile, MK-801, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, was shown to markedly reduce the expression of c-Fos in the trigeminal subnucleus caudalis (Vc) following noxious stimulation but to enhance c-Fos expression markedly in other brain regions, i.e., the neocortex, dorsal raphe and thalamic nuclei. In the present study, we examined the nature of c-Fos expression in the brainstem including the TSNC and midbrain following administration of MK-801 and/or experimental movement of the rat molars. Twelve hours after the beginning of experimental tooth movement, c-Fos was expressed bilaterally in the superficial laminae of Vc (Vc I/II), dorsomedial areas of the trigeminal subnucleus oralis (Vodm) and rostro-dorsomedial areas of the trigeminal subnucleus oralis (Vor) with the ipsilaterally dominant distribution, but hardly in the periaqueductal gray (PAG), dorsal raphe nucleus (DR) and Edinger-Westphal nucleus (EW). Intraperitoneal administration of MK-801 (0.03, 0.3 and 3.0 mg/kg) prior to the on...Continue Reading

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Citations

Oct 27, 2009·The Angle Orthodontist·Ana Paula Ribeiro NovaesChristie Ramos Andrade Leite-Panissi
Jul 18, 2014·Drugs·Kayi Chan, Antoinette MaassenVanDenBrink
Sep 26, 2014·Expert Opinion on Drug Metabolism & Toxicology·János TajtiLászló Vécsei
May 12, 2009·Expert Opinion on Investigational Drugs·Anna P Andreou, Peter J Goadsby
Jul 25, 2009·European Journal of Oral Sciences·Zhi YangZhenyu Liao
Dec 7, 2010·Pharmacology & Therapeutics·Kayi Y ChanAntoinette Maassenvandenbrink
Sep 29, 2012·Journal of Dental Research·M HasegawaK Iwata
Mar 7, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jan Hoffmann, Andrew Charles
Aug 9, 2020·Orthodontics & Craniofacial Research·Cui-Xia LiZe-Xu Gu
Apr 22, 2006·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Vinod Krishnan, Ze'ev Davidovitch

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