Administration of myelin basic protein synthetic peptides to multiple sclerosis patients

Journal of the Neurological Sciences
K G Warren, I Catz

Abstract

A double blind Phase 1 clinical research project was conducted in vivo in multiple sclerosis (MS) patients to determine the effect of myelin basic protein (MBP) synthetic peptides on free (F) and bound (B) titers of anti-MBP in cerebrospinal fluid (CSF). Intrathecal administration of peptide MBP75-95, either as a single dose, or as repeated injections for periods up to 10 weeks, produced complete binding-neutralization of F anti-MBP with no change in B levels. A control peptide MBP35-58 had no effect on F and B anti-MBP levels. Intravenous administration of MBP75-95 resulted in significant decline of F and B CSF anti-MBP levels over a period of one month. Administration of MBP synthetic peptides to MS patients either intrathecally or intravenously did not have any adverse neurological effects and systemic complications did not occur. The MBP epitope for MS anti-MBP was further localized to an area between Pro85 and Pro96.

Citations

Feb 21, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Dimitrios Karussis
Nov 1, 1995·Journal of the Neurological Sciences·S D Cook
Jan 13, 1998·Immunology Today·R LiblauH O McDevitt
Jul 2, 2005·Expert Opinion on Investigational Drugs·E G Spack
Mar 7, 2006·Biopolymers·Maria Claudia Alcaro, Anna Maria Papini
Dec 2, 2005·International Reviews of Immunology·Paulo FontouraLawrence Steinman
Jul 25, 2021·International Journal of Molecular Sciences·Inez WensNathalie Cools

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