PMID: 9165139Apr 1, 1997Paper

Administration of nicotinamide during a five- to seven-week course of radiotherapy: pharmacokinetics, tolerance, and compliance

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Johannes H A M KaandersA Rojas

Abstract

Nicotinamide was administered daily as a liquid formulation to head and neck cancer patients receiving a 5- to 7-week course of radiotherapy. The pharmacokinetics, compliance, and tolerance of this drug formulation were studied. Blood samples were drawn and nicotinamide levels determined in 40 head and neck cancer patients. On the first treatment day serial samples were obtained followed by daily samples at the time of irradiation during the first and last full weeks of the treatment. Side-effects of nicotinamide were monitored. In all patients peak concentrations greater than 700 nmol/ml could be obtained 0.25-3 h (mean 0.83 +/- 0.73 h) after drug intake. During the first week of treatment plasma levels at the time of irradiation were adequate in 82% of the samples. This decreased to 59% in the last week of treatment which can be partly attributed to reduced compliance. The most important side-effect of nicotinamide was nausea with or without vomiting occurring in 65% of the patients. Severe side-effects were associated with high plasma concentrations over subsequent days. Tolerance improved after a 25% reduction of dose in six of seven patients but plasma levels at the time of irradiation fell below 700 nmol/ml in four out of...Continue Reading

References

Sep 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M R StratfordR J Hodgkiss
Oct 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E KjellenA Rojas
Jan 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A Rojas
Apr 18, 1990·Journal of the National Cancer Institute·D J ChaplinM J Trotter
Aug 1, 1986·International Journal of Radiation Oncology, Biology, Physics·M R HorsmanW W Lee
Jun 1, 1981·Journal of the American Academy of Dermatology·H S ZachkeimC W Hastings
Jul 15, 1995·International Journal of Radiation Oncology, Biology, Physics·P J HoskinA Rojas
Jan 1, 1994·International Journal of Radiation Oncology, Biology, Physics·M J DorieJ M Brown
May 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M R HorsmanJ Overgaard
Sep 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J DragovicJ H Kim
Jan 15, 1996·International Journal of Radiation Oncology, Biology, Physics·A RojasH Johns
Dec 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J H KaandersW A van Daal

❮ Previous
Next ❯

Citations

Aug 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M W RuddockD G Hirst
Jul 27, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johan BussinkJohannes H A M Kaanders
Jan 10, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M I SaundersA M Rojas
Nov 30, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J BernierM Piérart
Feb 9, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S DischeS M Bentzen
Feb 19, 2002·International Journal of Radiation Oncology, Biology, Physics·Johannes H A M KaandersAlbert J van der Kogel
Dec 11, 2002·The Lancet Oncology·Johannes H A M KaandersAlbert J van der Kogel
Apr 7, 2006·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
Jan 5, 2002·Thyroid : Official Journal of the American Thyroid Association·M Agote Pisarev
Aug 28, 2012·The Journal of Clinical Investigation·Pierre KymeGeorge Y Liu
Aug 21, 2010·Journal of Nucleic Acids·Devita SurjanaDiona L Damian
Jun 20, 1998·Seminars in Radiation Oncology·D J ChaplinG M Tozer
Oct 11, 2005·International Journal of Radiation Oncology, Biology, Physics·Ilse J HoogsteenJohannes H A M Kaanders
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Geert O JanssensJohannes H Kaanders
May 5, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·P Wardman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
M W RuddockD G Hirst
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
M R HorsmanJ Overgaard
© 2021 Meta ULC. All rights reserved