Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis

Journal of Neuroimmunology
J ZielasekH P Hartung

Abstract

The nitric oxide (NO) synthase pathway is activated during experimental autoimmune inflammation of the central nervous system, and administration of aminoguanidine, an inhibitor of the cytokine-inducible NO synthase (NOS), ameliorated the disease course of autoimmune encephalomyelitis in the SJL mouse. We studied the role of nitric oxide synthase (NOS) in the pathogenesis of experimental autoimmune neuritis (EAN) and experimental autoimmune encephalomyelitis (EAE) in the Lewis rat. NG-L-monomethyl-arginine (L-NMMA), a competitive inhibitor of NOS, partially suppressed T cell line-mediated EAN, but not myelin-induced EAN, myelin basic protein (MBP)-induced EAE, or T cell line-mediated EAE. Aminoguanidine (AG), a selective inhibitor of the cytokine-inducible NOS, enhanced MBP-induced EAE, but had no significant effects on myelin-induced EAN. Two other NOS inhibitors, nitro-arginine methyl-ester and N-nitro arginine, had only little or no effects in EAN and EAE. The administration of NOS inhibitors showed some striking effects in EAN and EAE, but the observed diversity of actions points to a much more complex role of the NO pathway than previously suggested.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E GaleaD J Reis
May 15, 1991·Biochemical and Biophysical Research Communications·M A DwyerS H Snyder
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H P HammesM Brownlee
Dec 1, 1990·British Journal of Pharmacology·I R HutchesonN K Boughton-Smith
Jan 1, 1988·Annals of the New York Academy of Sciences·H P HartungK V Toyka
Mar 1, 1993·Glia·S B CorradinP Ricciardi-Castagnoli
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A CorbettE R Unanue
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G A BöhmeJ C Blanchard

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Citations

Jan 1, 1996·Springer Seminars in Immunopathology·H P HartungG Giegerich
Oct 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G S ScottC Bolton
May 1, 1997·Disease-a-month : DM·R G KilbournC Szabó
Jan 1, 1997·Journal of the Neurological Sciences·G GiovannoniE J Thompson
May 26, 1998·Journal of the Neurological Sciences·B G Xiao, H Link
Dec 31, 1997·Journal of Neuroimmunology·A H CrossT P Misko
Aug 4, 1998·Journal of Neuroimmunology·A H CrossT P Misko
May 6, 1999·Journal of Neuroimmunology·R C van der Veen, L J Roberts
Mar 1, 2000·Journal of Neuroimmunology·D O WillenborgW B Cowden
May 18, 2000·Journal of Neuroimmunology·J J BajramovićJ M van Noort
Mar 10, 2001·Progress in Neurobiology·R KieferH P Hartung
Jun 10, 1998·Cytokine & Growth Factor Reviews·B M Pratt, J M McPherson
Jul 10, 2003·Lancet Neurology·Kenneth J Smith, Hans Lassmann
Aug 23, 2001·International Immunopharmacology·R C van der Veen
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Wanda NiedbalaFoo Y Liew
Jun 6, 1998·The Journal of Experimental Medicine·C Bogdan
Jun 26, 2013·The Journal of Experimental Medicine· Jianjun YangHuabao Xiong
Jun 8, 2001·Journal of Neurotrauma·J XuC Y Hsu
Jun 27, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ehtishamul HaqInderjit Singh

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