Administration of porcine somatotropin by daily injection: growth and endocrine responses in genetically lean and obese barrows and gilts

Journal of Animal Science
J KlindtH J Mersmann

Abstract

Influences of genotype and sex on responses to porcine somatotropin (pST) administered by daily injection were examined in genetically lean and obese gilts and barrows. Pigs (59 +/- 1.4 kg BW, eight per pST dose x line x sex) were injected daily with pST at doses of 0, 2, and 4 mg/d for 6 wk. Administration of pST induced dose-dependent decreases in feed intake and rate of backfat deposition, whereas rate and efficiency of gain were increased in a quadratic manner indicating that 4 mg of pST/d approached the optimal dose. These live measures of growth were also influenced (P < .05) by sex and line. Line, sex, and pST dose effects (P < .05) were noted for most offal components and carcass components. Quantity of lean and bone in the ham was increased (P < .01) and that of fat decreased (P < .01) with dose of pST. Throughout the trial pST induced increases (P < .05) in serum concentrations of IGF-I, IGF-II, insulin, and glucose and decreases in urea nitrogen. Concentrations of pST 24 h after injection were lower (P < .05) in pST-injected pigs than in buffer-injected pigs, indicating negative feedback on endogenous pST secretion. The pST-induced increases (P < .05) in insulin, IGF-I, and IGF-II and the decrease in urea nitrogen we...Continue Reading

Citations

Mar 29, 2008·Metabolic Syndrome and Related Disorders·Thue Johansen, Kjell Malmlöf
Feb 12, 1998·The American Journal of Physiology·T J WesterD G Burrin
Aug 5, 1998·The American Journal of Physiology·T J LauterioR Ramirez

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