PMID: 8969394Dec 1, 1996Paper

Administration of propofol by target-controlled infusion in patients undergoing coronary artery surgery

Journal of Cardiothoracic and Vascular Anesthesia
L BarvaisA d'Hollander

Abstract

To study the predictive performance of a target-controlled infusion (TCI) system of propofol in patients undergoing coronary bypass graft (CABG) surgery, using a referenced pharmacokinetic set derived from healthy patients. Also, to determine the propofol concentrations required for clinically acceptable induction and maintenance of anesthesia when combined with midazolam as premedication and a continuous alfentanil infusion and to study the hemodynamic stability of this technique. Prospective noncomparative study analysis. Operating room at a university hospital. Twenty-on patients with good left ventricular function undergoing coronary artery surgery. Patients were anesthetized using a continuous infusion of alfentanil (mean infusion rate: 1 microgram/kg/min) and propofol administered by TCI. The predictive performance of the TCI system (212 arterial samples) was measured at specified time points before, during, and after bypass. The TCI system underestimated the measured blood propofol concentrations with a bias of +21.2% and +9.6% during the prebypass and the bypass periods, respectively. The predictive inaccuracy, expressed by the median absolute prediction error, was 23% and 18.5%, respectively. Mean target propofol conce...Continue Reading

References

Jul 1, 1991·British Journal of Anaesthesia·B MarshG N Kenny
Jun 1, 1991·British Journal of Anaesthesia·A R ManaraC Prys-Roberts
Feb 1, 1988·British Journal of Anaesthesia·T KirkpatrickW S Nimmo
Jun 1, 1994·Journal of Cardiothoracic and Vascular Anesthesia·L BarvaisE Coussaert
Jul 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M HynynenP H Rosenberg

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Citations

Mar 20, 2009·British Journal of Anaesthesia·J B Glen, F Servin
Jun 13, 2009·British Journal of Anaesthesia·A R AbsalomM M R F Struys
Feb 21, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Richard I Hall
Jun 24, 2003·Best Practice & Research. Clinical Anaesthesiology·F Wappler
Apr 9, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Gang MaJinhai Meng
May 30, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Iman A El-BarakyNirmeen A Sabry
Oct 12, 2004·European Journal of Anaesthesiology·J H HeijmansP M H J Roekaerts

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