PMID: 9546798Apr 18, 1998Paper

Administration of recombinant human interleukin 12 to chronically SIVmac-infected rhesus monkeys

AIDS Research and Human Retroviruses
N WatanabeN L Letvin

Abstract

With the demonstration that interleukin 12 can enhance natural killer (NK) cell activity and drive CD4+ lymphocytes toward T helper type 1 (Thl) responses, there is a strong rationale for exploring the use of this cytokine as an immunomodulatory therapy in HIV-1-infected individuals. To assess its potential safety and effects on both immune and virologic aspects of HIV-1 infection, recombinant human IL-12 (rhIL-12) was assessed in rhesus monkeys chronically infected with the simian immunodeficiency virus of macaques (SIVmac). The activity of rhIL-12 on rhesus monkey lymphocytes was confirmed with the demonstration that peripheral blood lymphocyte lysis of the NK-sensitive cell line Colo was enhanced by this recombinant cytokine. Further, rhIL-12 was shown to induce interferon-gamma production by rhesus monkey lymphocytes in vitro. Then, in separate studies, two treatment regimens of rhIL-12 were assessed in SIVmac-infected monkeys: a low-dose regimen (0.1 microg/kg, daily for 4 weeks) and a high-dose regimen (2.5 microg/kg, every 3-4 days, for 3 weeks). Both rhIL-12 treatment regimens were well tolerated by these virus-infected animals. The high-dose regimen of rhIL-12 induced transient decreases in circulating lymphocytes in t...Continue Reading

References

Sep 1, 1990·Immunology Today·N L Letvin
Apr 15, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C PachlB Irvine
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·S ChouaibF Mami-Chouaib
Apr 1, 1994·The Journal of Experimental Medicine·J ChehimiG Trinchieri

❮ Previous
Next ❯

Citations

Aug 21, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elizabeth A MillerNina Bhardwaj
Apr 29, 2004·Journal of Virology·Koen K A Van RompayNorbert Bischofberger
Jan 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Steven R LeongJuha Punnonen
Jul 6, 2012·Cytokine & Growth Factor Reviews·Suresh PallikkuthSavita Pahwa
Jun 19, 2013·Immunological Reviews·Elizabeth Miller, Nina Bhardwaj
Sep 22, 2006·Clinical and Vaccine Immunology : CVI·Geoffrey W StoneRichard S Kornbluth
Jul 27, 1999·Science·P D Greenberg, S R Riddell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.