PMID: 7540415May 1, 1995Paper

Administration of rHuGM-CSF activates monocyte reactive oxygen species secretion and adhesion molecule expression in vivo in patients following high-dose chemotherapy

British Journal of Haematology
M A WilliamsA C Newland

Abstract

Microbicidal and cytocidal products of the respiratory burst and integrin adhesion molecule expression have been studied in monocytes from patients who received rHuGM-CSF during regeneration after high-dose chemotherapy. In this study, administration of rHuGM-CSF after high-dose chemotherapy significantly augmented the secretion of inducible products of the monocyte respiratory burst. Monocyte activation persisted for several weeks after the cessation of GM-CSF therapy. Under in vitro conditions that mimicked gram-negative (LPS) and gram-positive (opsonized Staphylococcus aureus) sepsis, the monocyte responded to such stimulation by exhibiting an enhanced release of hydrogen peroxide at both regeneration and several weeks later (P < 0.001). Similarly, GM-CSF administration significantly augmented the phenotypic expression of the beta 2-integrin adhesion molecules and allowed the leucocyte-specific selectin, LAM-1, and the beta 2-integrins to respond normally to inflammatory stimulation by LPS. We further present evidence that GM-CSF therapy restored the otherwise refractory status of monocytes to inflammatory stimulation that existed in those patients given chemotherapy alone. The restoration of monocyte responsiveness by GM-CS...Continue Reading

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Citations

Nov 15, 2002·International Journal of Hematology·Adrian Newland
May 7, 1997·Transfusion Science·F Oberling
Jan 25, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M A WilliamsA C Newland
Nov 5, 2002·Critical Reviews in Oncology/hematology·A H KlimpT Daemen
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Oct 23, 1998·Pediatric Hematology and Oncology·E ErduranY Gedik
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc A WilliamsSteve N Georas

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