Administration-time-dependent effects of olmesartan on the ambulatory blood pressure of essential hypertension patients

Chronobiology International
Ramón C HermidaJosé R Fernández

Abstract

Previous studies established that a single daily dose of olmesartan remains effective for the entire 24 h without alteration of the day-night blood pressure (BP) pattern. On the other hand, the administration of valsartan or telmisartan at bedtime, as opposed to upon wakening, improves the sleep-time relative BP decline toward a greater dipper pattern without loss of 24 h efficacy. Yet to be determined is whether this administration-time-dependent efficacy is a class-related feature, characteristic of all angiotensin-receptor-blocker (ARB) medications. We studied 123 grade 1 and 2 hypertensive patients, 46.6+/-12.3 yrs of age, randomly assigned to receive olmesartan (20 mg/day) as a monotherapy either upon awakening or at bedtime for three months. BP was measured by ambulatory monitoring for 48 consecutive hours before and after treatment. The 24 h BP reduction was similar for both treatment times. Administration of olmesartan at bedtime, however, was significantly more efficient than morning administration in reducing the nocturnal BP mean. The sleep-time relative BP decline was slightly reduced with olmesartan ingestion upon awakening but significantly increased with ingestion at bedtime, thus reducing the prevalence of non-d...Continue Reading

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Citations

Sep 7, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ramón C HermidaFrancesco Portaluppi
Dec 15, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ramón C HermidaFrancesco Portaluppi
Nov 8, 2012·Chronobiology International·Michio FukudaGenjiro Kimura
Sep 26, 2012·Chronobiology International·Diana E AyalaRamón C Hermida
Sep 22, 2010·Chronobiology International·Francesco Portaluppi, Michael H Smolensky
Sep 22, 2010·Chronobiology International·Ramón C HermidaJosé R Fernández
Oct 20, 2012·Chronobiology International·Ramón C HermidaFrancesco Portaluppi
Oct 27, 2012·Chronobiology International·Juan J CrespoUNKNOWN Hygia Project Investigators
Oct 27, 2012·Chronobiology International·Diana E AyalaUNKNOWN Hygia Project Investigators
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