Admission serum phosphate levels predict hospital mortality

Hospital Practice
Wisit CheungpasitpornStephen B Erickson

Abstract

The aim of this study was to assess the relationship between admission serum phosphate levels and in-hospital mortality in all hospitalized patients. All adult hospitalized patients who had admission serum phosphate available between years 2009 and 2013 were enrolled. Admission serum phosphate was categorized based on its distribution into six groups (<2.5, 2.5-3.0, 3.1-3.6, 3.7-4.2, 4.3-4.8 and ≥4.9 mg/dL). The odds ratio (OR) of in-hospital mortality by admission serum phosphate, using the phosphate category of 3.1-3.6 mg/dL as the reference group, was obtained by logistic regression analysis. 42,336 patients were studied. The lowest incidence of in-hospital mortality was associated with a serum phosphate within 3.1-4.2 mg/dL. A U-shaped curve emerged demonstrating higher in-hospital mortality associated with both serum phosphate <3.1 and >4.2 mg/dL. After adjusting for potential confounders, both serum phosphate <2.5 and >4.2 mg/dL were associated with in-hospital mortality with ORs of 1.60 (95%CI 1.25-2.05), 1.60 (95%CI 1.29-1.97), and 3.89 (95%CI 3.20-4.74) when serum phosphate were <2.5, 4.3-4.8 and ≥4.9 mg/dL, respectively. Among subgroups of patients with chronic kidney disease (CKD) and cardiovascular disease (CVD), th...Continue Reading

References

Jul 1, 1987·Southern Medical Journal·A L KingS Pierpaoli
Jan 1, 1985·Intensive Care Medicine·J GoldsteinR J Kahn
Jan 29, 1972·British Medical Journal·M G Betro, R W Pain
Jan 1, 1983·Acta Medica Scandinavica·L LarssonB Sörbo
Mar 1, 1983·Chest·J FisherG Schulman
Nov 1, 1994·Journal of Clinical Epidemiology·M CharlsonJ Gold
Mar 1, 1997·Chest·R T SankaranP C Singhal
Mar 6, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Phillip Y ChungHelen S Te
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
Aug 7, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jonathan CohenPierre Singer
Dec 24, 2004·Journal of the American Society of Nephrology : JASN·Bryan KestenbaumDennis L Andress
Apr 9, 2005·Journal of the American Society of Nephrology : JASN·Yelena SlininAllan J Collins
Oct 26, 2005·Circulation·Marcello TonelliUNKNOWN Cholesterol And Recurrent Events Trial Investigators
May 16, 2007·Archives of Internal Medicine·Ravi DhingraRamachandran S Vasan
May 23, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nora VoormolenUNKNOWN PREPARE study group
May 2, 2008·Kidney International·Keith A HruskaRaymond Pratt
Sep 30, 2008·Journal of Clinical Pathology·M HoffmannR T Erasmus
Nov 7, 2008·Journal of the American Society of Nephrology : JASN·Robert N FoleyPhilip A Kalra
Dec 19, 2008·Journal of the American Society of Nephrology : JASN·Tamara IsakovaMyles Wolf
Feb 13, 2009·JAMA : the Journal of the American Medical Association·Catherine SullivanAshwini R Sehgal
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Aug 5, 2010·Critical Care : the Official Journal of the Critical Care Forum·Daniël A GeerseMarcus J Schultz
Oct 4, 2011·Atherosclerosis·Timothy J Ellam, Timothy J A Chico
Jan 14, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Biagio Di IorioUNKNOWN INDEPENDENT Study Investigators
Aug 24, 2012·Kidney International·Giovana Seno Di MarcoMarcus Brand
Feb 1, 2013·Kidney International·Dylan Burger, Adeera Levin
Mar 6, 2013·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Graeme O'Connor, Dasha Nicholls
Aug 1, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Priscilla GrossZiad A Massy
Mar 7, 2015·Journal of the American Society of Nephrology : JASN·Nima AbbasianAlan Bevington
Apr 27, 2017·American Journal of Nephrology·Simran K BhandariJohn J Sim
Oct 5, 2017·Journal of Nephrology·Charat ThongprayoonStephen B Erickson
Jan 10, 2018·International Journal of Clinical Practice·Charat ThongprayoonStephen B Erickson
Jan 31, 2018·Endocrine Research·Wisit CheungpasitpornStephen B Erickson

❮ Previous
Next ❯

Citations

Sep 5, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Giuseppe CoppolinoMichele Andreucci
Oct 9, 2020·BMC Nephrology·Charat ThongprayoonKianoush B Kashani
Jan 9, 2021·Clinical Science·Jakob VoelklCarsten A Wagner
Jan 15, 2020·Postgraduate Medical Journal·Yiftach BarashGadi Shlomai
Oct 23, 2020·Postgraduate Medical Journal·Charat ThongprayoonKianoush Kashani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.