Admixture analysis of age at onset in schizophrenia

Schizophrenia Research
F SchürhoffMarion Leboyer

Abstract

In schizophrenia, clinical, familial and biological characteristics according to age at onset (AAO) suggest that AAO is a valid candidate symptom for genetic studies. However, none of the various thresholds used to define AAO subgroups in schizophrenia has been validated. We aim to define different AAO subtypes by admixture analysis in a sample of prospectively recruited subjects with schizophrenia. Consecutive inpatients and outpatients (N=141) meeting DSM IV criteria for schizophrenia were included. We used admixture analysis to investigate whether the observed AAO distribution consisted of a mixture of gaussian distributions and then compared clinical features and familial risks in the various groups of subjects. The model that best fitted the observed AAO distribution was a mixture of two gaussian distributions (mean+/-S.D.): (19.91+/-3.56 years) and (33.48+/-8.2 years), with a cutoff point at 28 years. The existence of two subgroups according to AAO was further confirmed by the different clinical and familial profiles of these subgroups. The early-onset group consisted predominantly of male patients, with non-paranoid subtypes and with a higher familial risk of schizophrenia spectrum disorders and affective disorders. The ...Continue Reading

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Citations

Mar 21, 2007·Social Psychiatry and Psychiatric Epidemiology·Sebastian KöhlerLydia Krabbendam
Sep 15, 2012·Laterality·Pablo NajtMarkus Hausmann
Aug 31, 2013·General Hospital Psychiatry·Jerome J LiuVincenzo De Luca
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Sep 21, 2018·International Journal of Methods in Psychiatric Research·Baptiste PignonAndrei Szöke

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