Admixture analysis of age at symptom onset and age at disorder onset in a large sample of patients with obsessive-compulsive disorder

Journal of Affective Disorders
Umberto AlbertGiuseppe Maina

Abstract

A number of studies tested for the presence of different homogeneous subgroups of obsessive-compulsive disorder (OCD) patients depending on the age at onset (AAO). However, none of the various thresholds of AAO have been validated. No study examined whether age at symptoms onset (ASO) and age at disorder onset (ADO) each define specific and diverse OCD subgroups. We used normal distribution mixture analysis in a sample of 483 OCD patients to test whether we could identify subgroups of patients according to the AAO. We tested whether ASO and ADO had different distributions and identified different subgroups of OCD patients, and whether clinical correlates had similar patterns of associations with patients subgroups identified with ASO or ADO. The mixture analysis showed a trimodal distribution for ASO (mean ASO: 6.9 years for the early onset, 14.99 years for the intermediate onset, and 27.7 years for the late onset component), and confirmed a bimodal distribution for ADO (mean ADO: 18.0 and 29.5 years). Significant differences in the clinical profile of the subgroups emerged, particularly when identified using ASO. Limitations of our study are the retrospective investigation of AAO, and the fact that our sample may not represent...Continue Reading

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Citations

Sep 26, 2016·Journal of Anxiety Disorders·A SchatF G Zitman
Dec 21, 2016·International Journal of Psychiatry in Clinical Practice·Andrea AgugliaGiuseppe Maina
Feb 15, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Umberto AlbertGiuseppe Maina
Jul 8, 2016·International Clinical Psychopharmacology·Beatrice BenattiAlfredo Carlo Altamura
Feb 2, 2021·CNS Spectrums·Giacomo GrassiLuisa Vignozzi
May 26, 2021·Psychological Medicine·Behrang MahjaniChristie Burton

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