Admixture and genetic diversity distribution patterns of non-recombining lineages of Native American ancestry in Colombian populations

PloS One
Catarina XavierAna Goios

Abstract

Genetic diversity of present American populations results from very complex demographic events involving different types and degrees of admixture. Through the analysis of lineage markers such as mtDNA and Y chromosome it is possible to recover the original Native American haplotypes, which remained identical since the admixture events due to the absence of recombination. However, the decrease in the effective population sizes and the consequent genetic drift effects suffered by these populations during the European colonization resulted in the loss or under-representation of a substantial fraction of the Native American lineages. In this study, we aim to clarify how the diversity and distribution of uniparental lineages vary with the different demographic characteristics (size, degree of isolation) and the different levels of admixture of extant Native groups in Colombia. We present new data resulting from the analyses of mtDNA whole control region, Y chromosome SNP haplogroups and STR haplotypes, and autosomal ancestry informative insertion-deletion polymorphisms in Colombian individuals from different ethnic and linguistic groups. The results demonstrate that populations presenting a high proportion of non-Native American anc...Continue Reading

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Datasets Mentioned

BETA
EMP00538
YA003649
YA003818

Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

Arlequin
Geneious Pro
Multiplex Q
STRUCTURE
Haplogrep
Network
SNaPshot
EMMA
Phylotree
AIM

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