Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate.

Proceedings of the National Academy of Sciences of the United States of America
Gabriel BedoyaAndres Ruiz-Linares

Abstract

Although it is well established that Hispanics generally have a mixed Native American, African, and European ancestry, the dynamics of admixture at the foundation of Hispanic populations is heterogeneous and poorly documented. Genetic analyses are potentially very informative for probing the early demographic history of these populations. Here we evaluate the genetic structure and admixture dynamics of a province in northwest Colombia (Antioquia), which prior analyses indicate was founded mostly by Spanish men and native women. We examined surname, Y chromosome, and mtDNA diversity in a geographically structured sample of the region and obtained admixture estimates with highly informative autosomal and X chromosome markers. We found evidence of reduced surname diversity and support for the introduction of several common surnames by single founders, consistent with the isolation of Antioquia after the colonial period. Y chromosome and mtDNA data indicate little population substructure among founder Antioquian municipalities. Interestingly, despite a nearly complete Native American mtDNA background, Antioquia has a markedly predominant European ancestry at the autosomal and X chromosome level, which suggests that, after foundatio...Continue Reading

References

Oct 5, 1991·Lancet·S Macintyre, A Sooman
Feb 1, 1991·Genetics·J C Long
Jan 1, 1995·Genetics·D B GoldsteinM W Feldman
Dec 1, 1994·Human Molecular Genetics·M T SeielstadL L Cavalli-Sforza
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·P A UnderhillL L Cavalli-Sforza
Dec 5, 1998·American Journal of Human Genetics·E J ParraM D Shriver
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·F Austerlitz, E Heyer
Mar 11, 2000·American Journal of Human Genetics·L D GreenA Knight
Mar 31, 2000·American Journal of Human Genetics·J A DouglasK Lange
Mar 31, 2000·American Journal of Human Genetics·B Sykes, C Irven
Jun 30, 2000·American Journal of Human Genetics·J Alves-SilvaV F Prado
Oct 18, 2000·American Journal of Human Genetics·L G Carvajal-CarmonaA Ruiz-Linares
Nov 4, 2000·Nature Genetics·P A UnderhillP J Oefner
Nov 25, 2000·American Journal of Human Genetics·D R Carvalho-SilvaS D Pena
Jun 21, 2001·Annals of Human Genetics·P A UnderhillL L Cavalli-Sforza
Feb 6, 2002·Genome Research·UNKNOWN Y Chromosome Consortium
Feb 15, 2002·American Journal of Human Genetics·Heather E Collins-SchrammMichael F Seldin
Feb 26, 2003·Human Genetics·Luis G Carvajal-CarmonaAndrés Ruiz-Linares
Sep 27, 2003·American Journal of Human Genetics·Ewa ZietkiewiczDamian Labuda
Dec 24, 2003·American Journal of Human Genetics·Lev A ZhivotovskyLuba Kalaydjieva
Mar 31, 2005·Trends in Genetics : TIG·Evelyne HeyerFrédéric Austerlitz
Jul 14, 2005·Nature Reviews. Genetics·Michael W Smith, Stephen J O'Brien
Dec 29, 2005·American Journal of Human Genetics·Yali XueChris Tyler-Smith

❮ Previous
Next ❯

Citations

Oct 9, 2013·AIDS Research and Human Retroviruses·Wildeman ZapataMaría T Rugeles
Nov 7, 2009·Human Molecular Genetics·Nick PattersonVanessa M Hayes
Mar 25, 2011·Human Molecular Genetics·Conall M O'SeaghdhaW H Linda Kao
Feb 11, 2009·Molecular Biology and Evolution·Turi E King, Mark A Jobling
Jan 12, 2010·Annals of Human Genetics·Daniel CorachManfred Kayser
Nov 10, 2010·Annals of Human Genetics·Claudia MoreauDamian Labuda
Jul 27, 2007·Human Heredity·Vanessa F GonçalvesSérgio D J Pena
Oct 2, 2008·American Journal of Respiratory and Critical Care Medicine·Candelaria VergaraKathleen C Barnes
Jan 10, 2009·Journal of Dental Research·S Frazier-BowersE Lange
Mar 29, 2008·PLoS Genetics·Sijia WangAndrés Ruiz-Linares
Jan 5, 2014·PLoS Genetics·Simon GravelCarlos D Bustamante
Jun 19, 2013·PloS One·Claudia MoreauDamian Labuda
Oct 5, 2011·Genetics·Paul Verdu, Noah A Rosenberg
Mar 10, 2011·Nanomedicine·Emiliano GiardinaGiuseppe Novelli
Jul 12, 2011·Human Biology·D Castro De GuerraM Vívenes De Lugo
Dec 3, 2008·International Journal of Legal Medicine·Elzemar Martins Ribeiro RodriguesSidney Emanuel Batista dos Santos
Jul 16, 2014·Annals of Human Biology·Carlos Velez-PardoGabriel Bedoya
Oct 18, 2015·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·Noemí RivalderíaEsperanza Gutiérrez-Redomero
Feb 26, 2013·Forensic Science International. Genetics·Sergio CardosoMarian M de Pancorbo
Jan 8, 2016·Neurology. Neuroimmunology and Neuroinflammation·Jaime ToroHelena Groot de Restrepo
Aug 12, 2009·Trends in Genetics : TIG·Turi E King, Mark A Jobling
Apr 18, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·John CastiblancoJuan-Manuel Anaya
Feb 7, 2007·Virus Research·Marisol Devesa, Flor H Pujol
Jul 22, 2015·Scientific Reports·Lavanya RishishwarI King Jordan
Jan 14, 2009·American Journal of Physical Anthropology·Rodrigo Rubi-CastellanosHéctor Rangel-Villalobos

❮ Previous
Next ❯

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