Adolescent and adult rats' aversion to flavors previously paired with nicotine

Annals of the New York Academy of Sciences
Carrie E Wilmouth, Linda P Spear

Abstract

Despite the high prevalence of adolescent smoking, few studies have examined nicotine sensitivity during this developmental period. In the present study we examined adolescent and adult rats' preference/aversion for a flavor previously paired with nicotine. Paired (nicotine + Kool-Aid) and unpaired (Kool-Aid) solutions were presented in the home cage on alternating nights, with water given during the light phase for six days. A choice test was conducted 24 hr after the last night of conditioning, with both flavors presented simultaneously during the dark cycle. On test day, although the flavor previously paired with nicotine was not preferred at either age, adolescent rats consumed significantly more of the paired flavor than adults. These results suggest that adolescent rats are less sensitive to the aversive properties of nicotine. This finding taken together with adolescents' increased sensitivity to the rewarding properties of nicotine, may result in an increased vulnerability to nicotine dependence.

References

Jul 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Walter AdrianiGiovanni Laviola
Sep 6, 2002·Physiology & Behavior·Bonnie J VastolaLinda P Spear

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Citations

Jan 11, 2007·Psychopharmacology·Nicole L Schramm-SapytaCynthia M Kuhn
Jun 24, 2009·Psychopharmacology·Nicole L Schramm-SapytaCynthia M Kuhn
Jul 21, 2011·Psychopharmacology·James M Doherty, Kyle J Frantz
Jul 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hao ChenQingling Wu
Feb 9, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Junran CaoFrances M Leslie
May 18, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Megan J ShramAnh D Lê
Jun 22, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heidi R QuinnIain S McGregor
May 19, 2006·The Quarterly Journal of Experimental Psychology : QJEP·Mary C Olmstead
Jun 6, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Paula L Vieira-BrockDiana G Wilkins
Apr 23, 2013·Psychopharmacology·Rachel I AndersonElena I Varlinskaya
Oct 26, 2013·Psychopharmacology·Nicole L Schramm-SapytaCynthia M Kuhn
Dec 3, 2013·Neurotoxicology and Teratology·Linda Patia Spear
Apr 29, 2010·Pharmacology, Biochemistry, and Behavior·Junran CaoFrances M Leslie
Aug 25, 2009·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Chih-Ling HuangChia-Chen Lu
Mar 10, 2009·Pharmacology & Therapeutics·Jennifer B DwyerFrances M Leslie
Jan 13, 2009·Drug and Alcohol Dependence·Marilyn E CarrollJennifer L Perry
Dec 19, 2006·Neurotoxicology and Teratology·Susan C McQuownFrances M Leslie
Sep 24, 2010·Alcoholism, Clinical and Experimental Research·Nicole L Schramm-SapytaCynthia M Kuhn
Sep 24, 2010·Alcoholism, Clinical and Experimental Research·Rachel I AndersonLinda P Spear
May 16, 2012·Developmental Psychobiology·Zachary E HurwitzAnthony L Riley
Oct 30, 2013·Developmental Psychobiology·Zachary E HurwitzAnthony L Riley
Oct 7, 2011·Developmental Cognitive Neuroscience·Monique ErnstKyle Frantz
Mar 23, 2012·Developmental Cognitive Neuroscience·Graeme Fairchild
Jul 4, 2006·Pharmacology, Biochemistry, and Behavior·Nicole L Schramm-SapytaCynthia M Kuhn
Mar 31, 2016·Developmental Psychobiology·Carol A Dannenhoffer, Linda P Spear
Sep 20, 2011·Developmental Cognitive Neuroscience·Caitlin DrescherNicole L Schramm-Sapyta
Jun 1, 2013·Behavioural Brain Research·Andrew E ArrantCynthia M Kuhn
Jul 26, 2011·Pharmacology, Biochemistry, and Behavior·N S PentkowskiJ L Neisewander
Jun 16, 2010·Behavioural Brain Research·David A KupferschmidtA D Lê
Jul 16, 2014·Neuroscience and Biobehavioral Reviews·David M LydonCharles F Geier
Aug 28, 2012·Neuroscience and Biobehavioral Reviews·Andrey Verendeev, Anthony L Riley

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