Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperature

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Amir H Rezvani, Edward D Levin

Abstract

Alcohol and nicotine are the most widely abused drugs in the world. The use of these addictive drugs often begins in adolescence, however, little is known about the different impacts of nicotine and alcohol on adolescents versus adults. This study examined both the individual and combined effects of nicotine and alcohol on body temperature and locomotor activity in adolescent and adults rats. Rats were injected with saline (SC) + saline (IP), nicotine (SC) + saline (IP), alcohol (IP) + saline (SC) or alcohol (IP) + nicotine (SC). The dose selected for nicotine was 0.2 mg/kg and for alcohol 2.5 g/kg (16% v/v). For each age/treatment, 10-13 animals were used, with each animal receiving only one treatment. In regards to body temperature, both nicotine and alcohol caused a significant age x drug interaction. The combination of nicotine and alcohol caused greater drop in body temperature in adolescent than in adult rats. Neither of the two drugs, when given alone, caused differential effects in adolescents or adult rats, though both resulted in drop in body temperature. In terms of locomotor activity, the treatment that produced a significantly different effect between adolescents and adults was nicotine alone. Nicotine significantl...Continue Reading

References

May 1, 1992·Trends in Pharmacological Sciences·G F Koob
Mar 1, 1991·Alcoholism, Clinical and Experimental Research·C M de FiebreA C Collins
Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·E Museo, R A Wise
May 1, 1990·Alcohol·C M de FiebreA C Collins
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Jan 1, 1988·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C J GordonA H Rezvani
Feb 1, 1988·Pharmacology, Biochemistry, and Behavior·A C CollinsM J Marks
Sep 10, 1985·European Journal of Pharmacology·G Di Chiara, A Imperato
Oct 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·K YoshidaS Liljequist
Apr 1, 1995·Alcoholism, Clinical and Experimental Research·H S SwartzwelderM I Tayyeb
Jan 1, 1996·Psychopharmacology·E D Levin, D Torry
Dec 1, 1995·Alcoholism, Clinical and Experimental Research·H S SwartzwelderM I Tayyeb
Sep 1, 1996·Alcoholism, Clinical and Experimental Research·A C CollinsA E Bullock
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·P J LittleH S Swartzwelder
Sep 26, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·D M Lovinger
Jan 10, 1998·British Journal of Pharmacology·P J Covernton, J G Connolly
Mar 26, 1998·Alcoholism, Clinical and Experimental Research·G F KoobF Weiss
Apr 29, 1998·Journal of Addictive Diseases·N S Miller, M S Gold
May 20, 1998·Alcohol·H S SwartzwelderP J Little
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Amir H Rezvani, Edward D Levin
Jun 18, 2002·Alcoholism, Clinical and Experimental Research·NancyEllen C de FiebreChristopher M de Fiebre
Dec 14, 2002·Pharmacology, Biochemistry, and Behavior·Martha M FaradayNeil E Grunberg
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Martha M FaradayNeil E Grunberg
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Amir H Rezvani, Edward D Levin
Mar 17, 2004·Neuroscience and Biobehavioral Reviews·Anna Larsson, Jörgen A Engel

❮ Previous
Next ❯

Citations

Aug 29, 2006·Psychopharmacology·Francesco MussoGeorg Winterer
Jun 24, 2009·Psychopharmacology·Nicole L Schramm-SapytaCynthia M Kuhn
May 4, 2011·Behavioral Neuroscience·Tamara L Doremus-Fitzwater, Linda P Spear
Sep 10, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Frédéric LallemandPhilippe De Witte
Jun 18, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·John J CallaciPhillip Roper
Jun 28, 2011·Integrative and Comparative Biology·Carmi KorineBerry Pinshow
Jun 14, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Magalie LenoirEugene A Kiyatkin
Aug 23, 2011·Behavioural Brain Research·Edward D LevinAmir H Rezvani
Sep 18, 2007·Neurotoxicology and Teratology·Scott E BowenJenny L Wiley
Dec 16, 2006·Pharmacology, Biochemistry, and Behavior·Jun He, Fulton T Crews
Nov 23, 2006·Brain Research Bulletin·Pamela B YangNachum Dafny
Oct 6, 2005·Alcoholism, Clinical and Experimental Research·Susan BarronLinda P Spear
Sep 24, 2010·Alcoholism, Clinical and Experimental Research·Nicole L Schramm-SapytaCynthia M Kuhn
Nov 30, 2006·Neurotoxicology and Teratology·Eric P Nolley, Brian M Kelley
Nov 11, 2006·Neurotoxicology and Teratology·Jennifer M BrielmaierRobert F Smith
Jul 11, 2006·Neurotoxicology and Teratology·Lara K Aitchison, Robert N Hughes
Jul 27, 2006·Evaluation & the Health Professions·Susan L Ames, Colleen McBride
Feb 23, 2020·Tobacco Use Insights·Connie Hassett-Walker, Mark Shadden

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved